Basf Se Corporation

Evonik Degussa Gmbh

Wintershall Holding Gmbh

Paik Kwang Industrial Co., Ltd.

Basf Aktiengesellschaft

Evolva Sa

Stefan Haefner

Oskar Zelder

Hartwig Schröder

Corinna Klopprogge

Andrea Herold

Hartwig Schroder

Burkhard Kröger

Christoph Wittmann

Joanna Martyna Krawczyk

Esther Dantas Costa

Gregory Von Abendroth

Hansgeorg Ernst

Gregor Haberhauer

R Rogers Yocum

Holger Hartmann

Rajan Hollmann

Hartwig Schroeder

Edzard Scholten

Birgit Hoff

Mark K Williams

Aline Raddatz

Hans Gurski

Markus Pompejus

Xuqiu Tan

Thomas A Patterson

Mari Granström

Jochen Kutscher

Julia Kristiane Schmidt

Adrienne Huston Davenport

Judith Becker

Robert Thummer

Elmar Heinzle

Annegret Welzel

Klaus Ditrich

Karsten Koerber

Michael Breuer

Wolfgang Grabarse

Kai-Uwe Baldenius

Janice G Pero

Hans Wolfgang Hoeffken

Michael Naesby

Rainer Packe-Wirth

Tilo Habicher

Christophe Folly

Markus Schwab

Weol Kyu Jeong

Uwe Sauer

Nico Boehmer

Andreas Funke

Christian Fleck

René Stellmacher

Corrinna Klopprogge

Andreas Thywissen

Michael Seitter

Beata Brockmann

Curt Aimé Friis Nielsen

Juergen Reichert

Cristina Pop

Andrea Piatesi

Andrea Molt

Anaelle Hatsch

Thomas J Lyons

Michael Liszka

Carsten Schwalb

Anna Christine Schroer

Jörg Mampel

Anna Lange

Anja Knietsch

Benjamin J Lyons

Jens Kroemer

Theron Herman

Patrick Kiefer

Eudes De Crecy

Uwe Ruffer

Claudia Isabella Graef

Ewa Hughes

Asfia Qureshi

Anh-Huy Phan Le

Hugo Urbina

Michael Bueschel

Christian Riedele

Li-Wen Wang

Torsten Renz

Erich Kromm

Annegret Serwe

Beata Stosik

Dirk Daegele

Michael Friedrich Seitter

Michael Friedrich Hermann Seitter

Hartwig SCHRÖDER

The present invention relates to variants of an alpha-amylase which have an increased exoamylase activity compared to the parent alpha-amylase. The present invention also relates to methods of making the variant alpha-amylase and the use of the variant alpha-amylase in baking, detergents, personal care products, in the processing of textiles, in pulp and paper processing, in the production of ethanol, lignocellulosic ethanol or syrups and as viscosity breaker in oilfield and mining industries.

Amylase enzymes

The present invention relates to a method of producing a recombinant polypeptide a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 2 (CLR2) and to express said recombinant polypeptide. The method further relates to a filamentous fungus, which is genetically modified to decrease or eliminate the activity of CLR2 and the use of this filamentous fungus in the production of a recombinant polypeptide.

Method of producing proteins in filamentous fungi with decreased CLR2 activity

Described herein is a process of producing an organic compound, the process including: I) cultivating a genetically modified microorganism in a culture medium including sucrose as an assimilable carbon source to allow the genetically modified microorganism to produce the organic compound, and II) recovering the organic compound from the fermentation broth obtained in process step I) The genetically modified microorganism includes A) at least one genetic modification that leads to an increased activity of the enzyme encoded by the rbsK-gene, compared to the original microorganism that has not been genetically modified, and the original microorganism belongs to the family Pasteurellaceae. Also described herein are a genetically modified microorganism and the use thereof for the fermentative production of an organic compound from sucrose as an assimilable carbon source.

Process for producing an organic compound

Lipase enzymes and methods of using the lipases in a baking for improving the volume, stability, tolerance of a baked product and/or reducing and reducing or eliminating the use of DATEM.

Baking lipase and methods of use

The present invention relates to a method of producing a recombinant polypeptide in a filamentous fungus which is genetically modified to decrease or eliminate the activity of cellulase regulator 1 (CLR1) and to express the recombinant polypeptide. The method further relates to a filamentous fungus, which is genetically modified to decrease or eliminate the activity of CLR1 and to the use of this filamentous fungus in the production of a recombinant polypeptide.

Method of producing proteins in filamentous fungi with decreased CLR1 activity

The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium to which are fed, as assimilable carbon sources, glycerol and a further carbonaceous compound, to allow the microorganisms to produce the organic acid, thereby obtaining a fermentation broth comprising the organic acid; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein, at least for a certain period of time in process step I), the consumption rate of the further carbonaceous compound (Cin g per liter per hour) is lower than the maximum theoretical consumption rate of the further carbonaceous compound (CRin g per liter per hour).

Use of glycerol with limited feed of carbohydrates for fermentation

The present invention relates to a method for degrading DNA in a sample obtained by microbial fermentation or biotransformation, comprising treating the sample with a combination of increased temperature and low pH. It also relates to a method for releasing DNA from a microbial cell, comprising incubating the microbial cell at a temperature of 45&#xb0; C. to 55&#xb0; C. for two to ten hours. Finally, the present invention provides a method for producing a product, comprising a step of releasing DNA from a microbial cell and degrading said DNA.

Method of removing DNA from biotechnological products

The present invention relates to a modified microorganism having, compared to its wildtype, &#x2014;a reduced activity of an enzyme encoded by the ptsA-gene, &#x2014;a reduced activity of an enzyme encoded by the ptsH-gene or &#x2014;a reduced activity of an enzyme encoded by the ptsA-gene and a reduced activity of an enzyme encoded by the ptsH-gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae. The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.

Genetically modified microorganism for improved production of fine chemicals on sucrose

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the pykA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Microorganisms for succinic acid production

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the wcaJ-gene. The present invention also relates to a method for producing an organic compound and to the use of a modified microorganism.

Modified microorganism with improved biomass separation behaviour

The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography.

Microbial succinic acid producers and purification of succinic acid

The present invention relates to a modified microorganism having, compared to its wild-type, a reduced activity of the enzyme that is encoded by the fruA-gene. The present invention also relates to a method for producing an organic compound and to the use of modified microorganisms.

Modified microorganism for improved production of fine chemicals on sucrose

Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.

Genes and processes for the production of clavine-type alkaloids

The present invention relates to genetically modified microorganisms capable of producing beta-glucans, characterized in that the genetically modified microorganism overexpresses (i) a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity, and/or (ii) a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity, compared to a corresponding non-modified control microorganism of the same strain. The present invention also relates to the use of a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity or the use of such a polypeptide for producing &#x3b2;-glucans. Furthermore, the present invention relates to methods for producing &#x3b2;-glucans comprising the introduction of a promoter upstream of a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity thereby increasing the expression of the polynucleotide, or a polynucleotide encoding a polypeptide having 1,3-&#x3b2;-D-glucan synthase-activity into a microorganism being able to synthesize &#x3b2;-glucans.

Genetically modified microorganisms capable of producing &#x3b2;-glucans and methods for producing &#x3b2;-glucans

Genetically modified microorganisms capable of producing beta-glucans and methods for producing beta-glucans

Growing community of inventors

Speyer, Germany

Stefan Haefner