Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Universitãt Stuttgart

Etat Francais Represente Par Le Delegue General Pour L'armement

Europaisches Laboratorium Fur Molekularbiologie

Miltenyi Biotech B.v. & Co. Kg

Mab Factory Gmbh

Technische Universität Braunschweig / Institut Für Biochemie Und Biotechnologie

Miltenyi Biotec, Gmbh

Technische Universitat Braunschweig

Dübel, Stefan

Stefan Dübel

Michael Hust

Christophe De Romeuf

Melvyn Little

Holger Thie

Roland Kontermann

Frank Breitling

Christian Behrens

Meike Hutt

Annemarie Poustka

Lars Toleikis

Iris Klewinghaus

Oliver Seifert

Monilola Olayioye

Philippe Thullier

Thomas Schirrmann

Lisa Schmitt

Sarah-Jane Kellmann

Karl-Heinz Gross

Jonas Zantow

Rainer Saffrich

Doris Meier

Christian Menzel

Jana Mersmann

Mark Schütte

Thomas Jostock

Michael Braunagel

The invention provides an antigen-binding protein that specifically binds to a conformational epitope formed by domain III & IV of human epidermal growth factor receptor 3 (HER3) and antigen-binding proteins which compete therewith for binding, as well as fusion protein or conjugate comprising these. The invention also provides nucleic acid molecule comprising a sequence encoding said antigen binding proteins, vectors comprising the nucleic acid, and cells and pharmaceuticals comprising the antigen binding protein, the fusion protein, the nucleic acid, or the vector. The invention also provides the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical for use as a medicament. The invention further provides a method of inhibiting tumor growth or treating cancer, comprising administering a therapeutically effective amount of the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical.

Antigen binding protein against HER3

The present invention provides a composition comprising i) a polypeptide comprising calmodulin and two immunoglobulin superfamily domains, wherein said two immunoglobulin superfamily domains are linked via said calmodulin; ii) a calmodulin binding molecule; iii) ions binding to the Cabinding site of calmodulin; wherein the binding of said calmodulin-binding molecule and of said ions to said Cabinding site of calmodulin affects the binding of said polypeptide to an antigen to be bound by said polypeptide. The calmodulin may be a permutated calmodulin. A method for affecting the binding of a polypeptide for an antigen using said composition is also disclosed.

Composition and method for affecting the binding of antigen-binding polypeptides to antigens

For the combinatorial synthesis of molecule libraries, substances are embedded in a matrix consisting of a first solvent thereby forming transport units in a solid state of aggregation at a temperature of less than 90&#xb0; C. and wherein after application to a support, the physical environment of the transport units is modified by the application of a physical process such as a laser printer whereby the substances in the transport units are linked to the support.

Method and devices for applying substances to a support, especially monomers for the combinatorial synthesis of molecule libraries

Antibodies having a high specificity and high affinity towards the human gene product MUC1, which in specific variants is associated with neoplastic cells, i.e. tumor tissue, to the use of the antibodies for medical purposes, i.e. for tumor treatment, and for analytical purposes, e.g. for tumor diagnosis. Compositions comprising the antibodies, e.g. for use in the analytical processes and analysis, to pharmaceutical compositions comprising the antibodies, and to use of the antibodies in the manufacture of pharmaceutical compositions for tumor treatment or for diagnostic purposes.

Recombinant anti-MUC1 antibodies

The subject of the present invention is an anti-ricin antibody and the use thereof for the treatment of an individual suffering from ricin poisoning.

Anti-ricin antibody

Growing community of inventors

Braunschweig, Germany

Stefan Dübel