Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Gesellschaft Fuer Biotechnologische Forschung Mbh

Stefan Czichos

Gerhard Gross

Dan Gazit

Hubert Mayer

Gadi Pelled

Gadi Turgeman

Andrea Hoffmann

Yoram Zilberman

Joerg Lauber

The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another member of the T-box family.

Recombinant human cell for bone and cartilage cell formation

The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.

Methods and compositions for enhancing cartilage repair

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Braunschweig, Germany

Stefan Czichos