Pharmena Spolka Akcyjna (pharmena S.a.)

Cortria Corporation

Politechnika Lodzka

Angionica Sp. Z O.o.

Nattopharma As

Uniwersylet Jagiellonski

Uniwersytet Jagiellonski

Lipid Systems Sp. Z.o.o.

Pharmena S.a.

Hependo Sp. Z.o.o.

Stefan Chlopicki

Einars Loza

Ivars Kalvins

Jerzy Gebicki

Robert Bender

Andrzej Marcinek

Marek Langner

Tomasz Borowik

Magdalena Przybylo

Katarzyna Maresz

Marek K Janiak

Anna Bar

Marek Janiak

Malgorzata Urbaniak

Maria Walczak

Agnieszka Leszczynska

Micha Niemczak

Victor Adrianov

Kamil Kus

Brygida Marczyk

Grzegorz Kwiatkowski

Karol Kramkowski

A method for rapidly improving cardiovascular function, reducing arterial stiffness and reversing calcification of a blood vessel in a mammal comprising administering to the mammal an effective amount of vitamin K for a period of less than 6 months. Also a method for increasing endothelial nitric oxide production in mammals comprising administering to the mammal an effective amount of vitamin K for a period of less than 6 months. The vitamin K can be administered together with additional substances such as vitamin D.

Rapidly improving vascular conditions by administering vitamin K

A method for evaluating vascular endothelium function in a human subject comprises monitoring changes in intensity of NADH fluorescence signal emitted from skin tissue cells of an upper limb of said subject as a function of time, wherein said changes result from reactive hyperaemia caused by blocking and releasing blood flow in the same upper limb of said subject. A system for evaluating vascular endothelium function in a human subject comprises a means for illuminating a skin on an upper limb of said subject with exciting light, a means for measuring intensity of fluorescence signal emitted from the skin and recording changes of said intensity of the fluorescence signal over time; and a restriction means for blocking and releasing blood flow in the upper limb of said subject.

Method for evaluating vascular endothelium function and a system therefor

The present invention is directed to nicotinamide derivatives, and their use in treating lipoprotein abnormalities, alone or in combination with a statin.

1-methylnicotinaide derivatives and formulations of treatment of lipoprotein abnormalities

A method for the treatment or prevention of a cell or tissue damage in a living subject due to the exposure to ionizing radiation is provided, which comprises administration to said subject of a compound of formula (I) wherein R' is H, OH, CONHor COCH, R&#x2033; is H or CH, R&#x2032;&#x2033; is H or CH, and Xis a pharmaceutically acceptable counterion, in an amount sufficient to inhibit radiation-induced damage. 

Use of quaternary pyridinium salts as a therapeutic or preventing agent against ionizing radiation-induced damage

1-methylnicotinamide derivatives and formulations for treatment of lipoprotein abnormalities

The invention is directed to a method for enhancing prostacyclin levels in a mammal in need thereof, wherein the method includes administering a quaternary pyridinium salt of formula (I), wherein R is NH, CH, or N(H)CHOH group, and X is pharmaceutically acceptable counterion.

Use of quaternary pyridinium salts as vasoprotective agents

The invention is directed to a method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia by administration of a-methylnicotinamide salt.

Method for treating hypertriglyceridemia, dyslipidemia and hypercholesterolemia with a 1-methylnicotinamide salt

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Cracow, Poland

Stefan Chlopicki