Astrazeneca Ab

Spectracure Ab

Lumito Ab

Spectraphos Ab

Stefan Andersson-Engels

Sune Svanberg

Jonas Johansson

Staffan Folestad

Johan Axelsson

Ann Charlotte Johansson

Johannes Swartling

Katarina Svanberg

Christoffer Abrahamsson

Niclas Svensson

Can Xu

Pontus Svenmarker

Haichun Liu

Christoffer Abrahamson

Mikael Sjöholm

Gabriel Somesfalean

Unne Stenram

Ann Johansson

A method and system for luminescence molecular imaging or tomography of a region of interest in a scattering medium is disclosed. The system comprises a non-linear luminescent marker material arranged in the scattering medium. Contrast and resolution of the imaging or tomography is thus improved. The non-linear marker is for instance configured to upconvert incoming light of an illumination wavelength. The non-linear power dependence of the marker enables further improvement of the imaging by using images taken with two or more excitation beams simultaneously.

System, method, and luminescent marker for improved diffuse luminescent imaging or tomography in scattering media

A method and system for controlling and adjusting light in interstitial photodynamic light therapy (IPDT) in a subject is disclosed. More particularly, a method for controlling the light in interstitial tumor photodynamic light therapy is described using a calculation method for determination of status of tissue during the PDT treatment. The status is used in a feedback loop to control the continued PDT treatment. Methods are disclosed that constitute pre-treatment and realtime dosimetry modules for IPDT on the whole prostate glandular tissue. The method includes reconstruction of the target geometry, optimization of source fiber positions within this geometry, monitoring of the light attenuation during the treatment procedure and updating individual fiber irradiation times to take into account any variation in tissue light transmission. A control device that is arranged to restrict delivery of therapeutic light treatment at least temporary in dependence of at least one attribute of one of photodynamic treatment parameters. In comparison to no treatment feedback, a significant undertreatment of the patient as well as damage to healthy organs at risk are avoided.

System and method for controlling and adjusting interstitial photodynamic light therapy parameters

A system for providing interstitial photodynamic and/or photothermal therapy on a region of tissue in a body, comprising at least one light source adapted to deliver a therapeutic light to the region of tissue, such that the light source is interstitially inserted into the tissue for interaction with a photosensitizer agent and/or for providing a controlled thermal environment of the tissue; and a unit for determining an optimized number of the light sources and individual position of each of the light sources in the region of tissue as well as individual control parameters for each of the light sources.

System and method for pre-treatment planning of photodynamic light therapy

The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample () is irradiated with an excitation beam () of radiation, e.g. near infrared radiation. The intensity of emitted radiation () from the sample () is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (). Optionally, the intensity of the emitted radiation () from the sample () is also detected in a spatially resolved manner.

Measuring technique

The present invention relates to a method for analysing the amount of free gas within a pharmaceutical sample. According to the invention the method comprises the following steps: providing a sample before an irradiating source; irradiating the sample with at least one beam of electromagnetic radiation; detecting radiation emitted through the sample and generating signals corresponding to the amount of free gas in the sample, and correlating the generated signals to at least one solid state parameter of the sample.

Method of analysing a pharmaceutical sample

A distributor for a system for interactive interstitial photodynamic and photothermal tumor therapy and tumor diagnosis, comprises a plurality of primary radiation conductors arranged for conducting radiation to and from the tumor site, a plurality of secondary radiation conductors, two flat discs abutting against each other, wherein a first of said discs is fixed and the second of said discs is turnable relatively to the other disc, and each disc has holes arranged on a circular line. The proximal ends of the primary radiation conductors are fixed in the holes of the fixed disc and distal ends of the secondary radiation conductors are fixed in the holes of the turnable disc, whereby the primary and the secondary radiation conductors by rotation of the turnable disc are connectable to each other in different constellations.

Therapy and diagnosis system and method with distributor for distribution of radiation

Diagnosis by means of fluorescent light emission from tissue

Growing community of inventors

Lund, Sweden

Stefan Andersson-Engels