Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Ustav Experimentalni Botaniky Av Cr, V.v.i.

Stefaan Werbrouck

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

Igor Popa

René Lenobel

Jan Holub

Borivoj Vojtesek

Frank J Massino

Dana Hradecká

Stjepan Uldrijan

Petr Mlejnek

Dana Hradeck

Novel heterocyclic derivatives based on N-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

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The invention concerns novel substitution derivatives of N-benzyladenosine having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells. This invention also relates to the methods of preparation of these N-benzyladenosine derivatives and their use as drugs, cosmetic preparations and growth regulators comprising these derivatives as active compound and use of these derivatives for preparation of pharmaceutical compositions, in biotechnological processes, in cosmetics and in agriculture.

Heterocyclic derivatives based on N-substituted adenine of, e.g.,a formula: wherein R2 is hydrogen, R6 is R6'-X, X is &#x2014;NH&#x2014;, and R6&#x2032; is substituted phenyl or substituted benzyl. The derivatives possess anticancer, mitotic, imunosuppressive and antisenescent properties for plant, animal and human cells, and methods of their preparation are disclosed. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

Growing community of inventors

Harelbeke, Belgium

Stefaan Werbrouck