Genmab A+s

Steen Lisby

Paul Parren

Jan Van De Winkel

Patrick Van Berkel

Sandra Verploegen

David Satijn

Ole Baadsgaard

Wim Bleeker

Yvo Graus

Martine Van Vugt

Klaus Edvardsen

Marije Overdijk

Willem Karel Bleeker

Michel De Weers

Judith Oprins

Riemke Van Dijkhuizen

Nancy Cherry Whiting

Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed.

Human antibodies and antibody-drug conjugates against CD74

Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapies and diagnostic methods for using the antibodies and antibody drug conjugates.

Human antibody drug conjugates against tissue factor

The invention relates to a method for the treatment of a disease susceptible to anti-EGFR treatment, comprising the step of administering, to a human being in nee thereof, a combination of an anti-EGFR agent and an anti-neutrophil-chemoattracta agent, wherein said anti-neutrophil-chemoattractant agent is administered in a dosage regimen that is sufficient to reduce one or more undesired dermatological side-effects the anti-EGFR agent. In one embodiment, the anti-EGFR agent is an anti-EGF antibody and the anti-neutrophil-chemoattractant agent is an anti-IL-8 antibody.

Method of treating rash in patients undergoing anti-EGFR therapy

Antibody drug conjugates against tissue factor. Also disclosed are pharmaceutical compositions comprising the antibodies and antibody drug conjugates, and therapeutic and diagnostic methods for using the antibodies and antibody drug conjugates.

The invention relates to novel method for the treatment of cancer using a combination therapy comprising an antibody that binds CD38, a corticosteroid and a non-corticosteroid chemotherapeutic agent.

Combination treatment of CD38-expressing tumors

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Frederiksberg, Denmark

Steen Lisby