Percutaneous Cardiovascular Solutions Pty Ltd

Stayajit Rohan Jayasinghe

Suku Thambar

Stefan G Schreck

Martin Christopher Cook

A percutaneous heart valve prosthesis including a collapsible valve body frame has a first end and a second end. The valve body frame is formed by a plurality of sub-frame members, each sub-frame member having a general form of a diamond with acute-angled vertices and oblique-angled vertices, wherein adjacent sub-frame members are joined at the oblique-angled vertices. A flexible skirt made from a non-biologic material extends around a periphery of the valve body frame. A one-way valve including a plurality of flexible valve leaflets is positioned within the valve body frame. The first end of the valve body frame is sized to pass through a valve orifice associated with a heart valve to be replaced and the second end of the valve body frame is sized so as not to pass through a valve orifice.

Percutaneous heart valve prosthesis

A method of implanting a percutaneous heart valve prosthesis via a catheter. The heart valve prosthesis includes a valve body frame made of a nickel-titanium alloy. The valve body frame is collapsible for fitting within the catheter. A flexible skirt is sutured to the valve body frame for blocking retrograde blood flow. A one-way valve is positioned within the valve body frame for permitting blood to flow from a first end of the valve body frame to a second end. The one-way valve is preferably formed by three flexible valve leaflets made from a pericardial material. A plurality of barbs is spaced about the periphery of the valve body frame. Each of the prongs points toward the first end of the valve body frame for preventing migration of the heart valve prosthesis towards an atrium of the heart.

Method of implanting a heart valve prosthesis

A percutaneous heart valve prosthesis including a collapsible valve body frame has a first end and a second end. The valve body frame is formed by a plurality of sub-frame members, each sub-frame member having a general form of a diamond with acute-angled vertices and oblique-angled vertices, wherein adjacent sub-frame members are joined at the oblique-angled vertices. A flexible skirt made from pericardial material extends around a periphery of the valve body frame. A one-way valve including a plurality of flexible valve leaflets is positioned within the valve body frame. The first end of the valve body frame is sized to pass through a valve orifice associated with a heart valve to be replaced and the second end of the valve body frame is sized so as not to pass through a valve orifice.

A method of implanting a percutaneous heart valve prosthesis via a catheter. The heart valve includes a valve body frame made of a nickel-titanium alloy. The valve body frame is collapsible for fitting within the catheter. A flexible skirt is sutured to the valve body frame for blocking blood flow between the valve body frame and native tissue. A one-way valve is positioned within the valve body frame for permitting blood to flow from a first end of the valve body frame to a second end. The one-way valve is preferably formed by three flexible valve leaflets made from a pericardial material. A plurality of barbs are spaced about the periphery of the valve body frame. Each of the barbs points toward the first end of the valve body frame and at least some of the barbs are positioned at the second end of the valve body frame.

A mitral valve prosthesis includes a valve body frame made of a nickel-titanium alloy. The valve body frame is collapsible for fitting within a catheter for delivery. A flexible skirt is sutured to the valve body frame for blocking blood flow between the valve body frame and native mitral valve tissue. A one-way valve is positioned within the valve body frame for permitting blood to flow from a first end of the valve body frame to a second end of the valve body frame. The one-way valve is preferably formed by three flexible valve leaflets made from a pericardial material. A plurality of barbs are spaced about the periphery of the valve body frame. Each of the barbs points toward the first end of the valve body frame and at least some of the barbs are positioned at the second end of the valve body frame.

A method of treating a heart includes radially expanding a housing component within a native atrioventricular valve. The housing component includes an atrial anchoring mechanism for deployment in the left atrium and ventricular prongs for engagement with native tissue in the left ventricle. The housing component also includes an interior passageway sized for receiving a valve component. After the housing component has been deployed, the valve component is radially expanded within the passageway of the housing component. The valve component includes three leaflets configured for allowing blood to flow from the left atrium to the left ventricle. After expansion within the housing component, the valve component may have an inflow end portion that protrudes above the housing component into the left atrium. The housing component and valve component are preferably collapsible for advancement through a patient's vasculature using one or more catheters.

Heart valve prosthesis and method

A percutaneous heart valve prosthesis () has a valve body () with a passage () extending between the first and second ends () of the valve body (). The valve body () is collapsible about a longitudinal axis () of the passage () for delivery of the valve body () via a catheter (). One or more flexible valve leaflets () are secured to the valve body () and extend across the passage () for blocking bloodflow in one direction through the passage (). An anchor device (), which is also collapsible for delivery via catheter (), is secured to the valve body () by way of an anchor line (). A failed or failing mitral heart valve () is treated by percutaneously locating the valve body () in the mitral valve orifice () with the anchor device () located in the right atrium () and engaging the inter-atrial septum (), such that the taught anchor line () acts to secure the valve body () within the mitral valve orifice ().

A heart valve prosthesis () comprises a housing component () and a valve component (). The housing component () comprises a housing body () having a housing passage () extending therethrough. The housing body () is configured to be located in, or adjacent to and communicating with, a native valve orifice () of a heart () and to engage structure of the heart () to fix the housing body () in relation to the valve orifice (). The housing component () is collapsible for delivery via catheter (). The valve component () comprises a valve body () having a valve passage () extending therethrough. The valve body () is configured to be fixed within the housing passage () with the valve passage () extending along the housing passage (). One or more flexible valve elements () is/are secured to the valve body and extend across the valve passage () for blocking blood flow in a first direction through the valve passage () whilst allowing blood flow in the opposing direction. The valve component () is collapsible for delivery via catheter () separate to the housing component (). An associated method of replacing a failed or failing heart valve utilising the heart valve prosthesis () is also disclosed.

A percutaneous heart valve prosthesis () has a valve body () with a passage () extending between the first and second ends () of the valve body (). The valve body () is collapsible about a longitudinal axis () of the passage () for delivery of the valve body () via a catheter (). One or more flexible valve leaflets () are secured to the valve body () and extend across the passage () for blocking bloodflow in one direction through the passage (). An anchor device (), which is also collapsible for delivery via catheter (), is secured to the valve body () by way of an anchor line ().

Growing community of inventors

Southport, Australia

Stayajit Rohan Jayasinghe