Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Stanley Wertheimer

Matthias Heinrich Nettekoven

Werner Neidhart

Jean Ackermann

Aurelia Conte

Daniel Hunziker

Tanja Schulz-Gasch

Stephan Brugger

The invention provides novel compounds having the general formula (I) wherein R, R, Rand A are as described herein, compositions including the compounds and methods of using the compounds.

Azacyclic compounds

The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts thereof. The are useful as HSL inhibitors and may, for example, be used in treatment of diabetes, metabolic syndrome, dyslipidemia, atherosclerosis, and obesity.

HSL inhibitors useful in the treatment of diabetes

Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein A, A, R, R, Rand Rhave the significance given in claim

Piperidine derivatives

Compounds of formula (I) as well as pharmaceutically acceptable salts thereof can be used in the form of pharmaceutical compositions, wherein R, R, Rand n have the significance given in claim

Azacyclic derivatives

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, m, A, Rand Rhave the significance given in the description. The compounds are useful as HSL inhibitors and may be used in the treatment or prophylaxis of diabetes, dyslipidemia, atherosclerosis or obesity.

The present invention relates to compounds of formula (I) as well as pharmaceutically acceptable salts thereof, wherein A, A, R, R, R, R, Rand Rhave the significance given herein.

The invention provides novel compounds having the general formula (I) wherein R, Rand A are as described herein, compositions including the compounds and methods of using the compounds. The compounds inhibit hormone sensitive lipase (HSL) and may be used in the treatment of diabetes, metabolic syndrome, and obesity.

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Croton, NY, United States of America

Stanley Wertheimer