Pfizer Corporation

Pfizer Products Inc.

Stanley W Walinsky

John F Lambert

Joseph Philip Rainville

Frank R Busch

Terry G Sinay

Terry Gene Sinay, Jr

Russell J Shine

Kathleen D Goggin

Randel E Stong

Darrell E Fox

Subramanian Sam Guhan

Paul D Hill

Robert Mark Guinn

William M Snyder

Douglas J Allan

Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol

Process for the preparation of 2-(4-alkyl-1-piperazinyl)-benzaldehyde and -benzylidenyl compounds

Process for the preparation of the mesylate salt trihydrate of 1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidin-1-yl)-1-propanol and intermediates useful therefor

The present invention relates to alatrofloxacin mesylate substantially free of less polar impurities, to parenteral compositions of alatrofloxacin mesylate and to processes for purifying alatrofloxacin mesylate.

Alatrofloxacin parenteral compositions

Processes and intermediates for preparing

The present invention relates to a pro-drug of ziprasidone or pharmaceutically acceptable salts thereof, processes for its preparation, and pharmaceutical compositions and methods of treatment comprising said pro-drug.

Pro-drugs of

Process for steroidal peracyl glycosides

Process for making .beta.-O-cellobiosyl steroid derivatives and

Method for making steroidal peracyl glycosides

Substantially homogeneous (meth)acrylic acid/itaconic acid copolymers of number average molecular weight of 500 to 7000 are prepared by copolymerizing in aqueous solution 5 to 90 mole percent acrylic or methacrylic acid monomer with 95 to 10 mole percent itaconic acid monomer at 80.degree. to 120.degree. C. in the presence of a polymerization initiator, the acrylic or methacrylic acid monomer and at least half of the initiator being added separately and continuously to the itaconic acid monomer throughout the polymerization period. The copolymers are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.

(Meth)acrylic acid/itaconic acid copolymers, their preparation and use

Processes for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)

Substantially homogeneous acrylate/maleate copolymers of number average molecular weight of 500 to 5000 are prepared by copolymerizing 35 to 65 mole percent acrylic or methacrylic acid with 65 to 35 mole percent maleic anhydride at 80.degree. to 150.degree. C. in the presence of a polymerization initiator and a chain-transfer solvent such that both the monomers and the formed polymer remain in solution and the mole ratio of the acrylic or methacrylic acid monomer to the maleic anhydride monomer in the solvent is maintained below about 0.2 throughout the polymerization. The copolymers in hydrolyzed form are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.

Substantially homogeneous copolymers of acrylic or methacrylic acid and

An aqueous drilling fluid suitable for high-temperature use comprising a water base, clay suspended in said base and from about 0.01-25 pounds per barrel total composition of a hydrolyzed terpolymer of maleic anhydride, styrene and a third monomer selected from acrylamide, methacrylamide, acrylic acid or methacrylic acid, the molar ratio of maleic anhydride to styrene to said third monomer being from about 30:10:60 to 50:40:10, and the alkali metal, ammonium and lower aliphatic amine salts thereof, the weight-average molecular weight of said hydrolyzed terpolymer being from about 500-10,000. An improved drilling process wherein such fluids remain flowable at elevated temperatures is also disclosed.

High temperature drilling fluids

Acrylate/maleate copolymers, their preparation and use as antiscalants

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Mystic, CT, United States of America

Stanley W Walinsky