The Children's Hospital of Philadelphia

Stanley Stachelek

Robert J Levy

Ivan Alferiev

Abigail Christian

Jeanne M Connolly

Oxidation resistant bioprosthetic tissues and oxidation resistant bioprosthetic heart valve leaflets are described. Also provided are methods for preparing the oxidation resistant bioprosthetic tissues and bioprosthetic heart valve leaflets, and methods for preventing oxidative degeneration in bioprosthetic tissues, including immobilizing covalently an effective amount of an antioxidant to the bioprosthetic tissue.

Oxidation resistant bioprosthetic tissues and preparation thereof

A polymer is provided according to structure I wherein Y is a thiol-reactive group and Z is an ionogenic group. The surface of a polymeric substrate is modified by contacting the surface with a polymer according to structure II or structure III and exposing the surface to ultraviolet light, optionally followed by contacting the modified surface with the polymer according to structure I. 

Photo-activated attachment of cholesterol to polyurethane surfaces for adhesion of endothelial cells

A modified polyurethane including a lipid substituent pendant from at least one urethane nitrogen and/or at least one carbon atom of the modified polyurethane, methods of preparing modified polyurethanes and the use thereof as an implantable biomaterial.

Steroid lipid-modified polyurethane as an implantable biomaterial, the preparation and uses thereof

A modified polyurethane including a lipid substituent from at least one urethane nitrogen and/or at least carbon atom of the modified polyurethane.

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Philadelphia, PA, United States of America

Stanley Stachelek