Luminescent Technologies, Inc.

Level Set Systems Inc.

University of California

Stanley Joel Osher

Danping Peng

Daniel S Abrams

Bin Dong

Barry Lynn Merriman

Hong-Kai Zhao

Paul S Weiss

Aichi Chien

Andrea L Bertozzi

Pradeep Thiyanaratnam

Anne M Andrews

Yu Mao

Li-Tien Cheng

Haomin Zhou

Systems and methods of fabricating and functionality patterned nanowire probes that are stable under fluid reservoir conditions and have imageable contrast are provided. Optical imaging and deconstruction methods and systems are also provided that are capable of determining the distribution of nanowires of a particular pattern to determine the mixing between or leakage from fluid reservoirs.

Determining fluid reservoir connectivity using nanowire probes

This invention relates to a method and apparatus for accurate compression and decompression of data. More specifically, this invention relates to a method and apparatus for compressing three dimensional spatial points (so called 'point cloud') and decompressing such data to produce an accurate point cloud. In one embodiment of the present invention, a level set based method is used to reconstruct a surface to approximate the surface of the point cloud. This reconstructed surface is defined implicitly as the zero level set of a function, which can be computed on a regular three-dimensional rectangular grid. Furthermore, the three-dimensional grid may be rearranged into a two-dimensional grid where the data are compressed and stored in a form of gradient. In order to recover the point cloud, the three-dimensional grid is rebuilt from the two-dimensional data and an interpolating algorithm on the implicit function is utilized to compute the points on the surface.

Method and apparatus for accurate compression and decompression of three-dimensional point cloud data

A method and apparatus for volumetric image analysis and processing is described. Using the method and apparatus, it is possible to obtain geometrical information from multi-dimensional (3D or more) images. As long as an object can be reconstructed as a 3D object, regardless of the source of the images, the method and apparatus can be used to segment the target (in 3D) from the rest of the structure and to obtain the target's geometric information, such as volume and curvature.

Apparatus and method for surface capturing and volumetric analysis of multidimensional images

This invention relates to a method and apparatus for image processing, and more particularly, this invention relates to a method and apparatus for processing image data generated by bioanalytical devices, such as DNA sequencers. An object of the present invention is to remove artifacts such as noise, blur, background, non-uniform illumination, lack of registration, and extract pixel signals back to DNA-beads in a way that de-mixes pixels that contain contributions from nearby beads. In one aspect of the present invention, a system for optimizing an image comprises means for receiving an initial image which includes a plurality of microparticles with different intensities; a computing device, comprising a processor executing instructions to perform: generating an initial function denoting each microparticle's location and intensity in the initial image; determining an image processing operator adapted to determine an extent of point spread and blurriness in the initial image; computing an optimum function denoting each microparticle's location and intensity in an optimizing image; and producing the optimizing image with enhanced accuracy and density of the microparticles.

Method and apparatus for image processing for massive parallel DNA sequencing

Photomask patterns are represented using contours defined by level-set functions. Given target pattern, contours are optimized such that defined photomask, when used in photolithographic process, prints wafer pattern faithful to target pattern. Optimization utilizes 'merit function' for encoding aspects of photolithographic process, preferences relating to resulting pattern (e.g. restriction to rectilinear patterns), robustness against process variations, as well as restrictions imposed relating to practical and economic manufacturability of photomasks.

Method for time-evolving rectilinear contours representing photo masks

A method for determining a mask pattern to be used on a photo-mask in a photolithographic process is described. During the method, a target pattern is partitioning into subsets, which are distributed to processors. Then, a set of second mask patterns, each of which corresponds to one of the subsets, is determined. Moreover, at least one of the second set of mask patterns may be determined by: providing a first mask pattern that includes distinct types of regions corresponding to distinct types of regions of the photo-mask, calculating a gradient of a function, and determining a second mask pattern based, at least in part, on the gradient. Note that the function may depend on the first mask pattern and an estimate of a wafer pattern that results from the photolithographic process, and that the gradient may be calculated in accordance with a formula obtained by taking a derivative of the function.

Systems, masks, and methods for photolithography

Technique for determining a mask pattern corresponding to a photo-mask

Optimized photomasks for photolithography

A method and apparatus for compression and restoration of images, videos, surfaces, curves and, generally, pixel-based data sets, including: feature-based quantization using a set of N isocontours; compressing each of these N contours using a level set-based compression of curves or surfaces&#x2014;and/or combining the quantization with a conventional method for compression of surfaces; and decompressing the compressed data using a nonoscillatory reconstruction. The method is naturally multiscale, but does not use wavelets or other multiscale-basis functions. The method performs compression and decompression (1) without excessive computational complexity, even in the presence of topological changes such as merging or breaking of isocontours as the scale changes, (2) with excellent image fidelity, (3) without unacceptable artifacts such as ringing, blurring, or blocking, (4) with simple and natural grid based ways of calculating geometric features such as normals, principal curvatures.

Growing community of inventors

Pacific Palisades, CA, United States of America

Stanley Joel Osher