Dana-Farber-Cancer Institute Inc.

Washington University

Harvard College

Whitehead Institute for Biomedical Research

Howard Hughes Medical Institute

Aileron Therapeutics, Inc.

Stanley J Korsmeyer

Loren D Walensky

Gregory Lawrence Verdine

Anthony Letai

Federico Bernal

Susan Korsmeyer, Legal Representative

Luca Scorrano

Gregory H Bird

Todd R Golub

Scott A Armstrong

Paul H Schlesinger

James J D Hsieh

Nika N Danial

Emily H Y Cheng

Atan Gross

Loren D Walenski

Gregory c/o Havard University Verdine

Frederico Bernal

The invention provides peptides and the nucleic acid sequences that encode them. The invention further provides therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders.

BH3 peptides and methods of use thereof

The invention provides composition and therapeutic, methods for modulating homeostatic pathways that are useful in treatment, and prevention of diabetes, diabetes associated disorders, metabolic disorders and cancer.

Methods of modulating cellular homeostatic pathways and cellular survival

Cross-linked peptides related to human p53 and bind to HMD2 or a family member of HDM2 useful for promoting apoptosis, e.g., in the treatment of and identifying therapeutic agents that binding to HMD2 or a family member of HDM2.

Stabilized P53 peptides and uses thereof

BH3 peptides and method of use thereof

Stabilized p53 peptides and uses thereof

Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking ('hydrocarbon stapling') moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polypeptide. The polypeptides described herein can be used to treat diseases characterized by excessive or inadequate cellular death.

Stabilized alpha helical peptides and uses thereof

A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.

Inhibitors of Taspase1 protease activity

Disclosed herein are novel polypeptides and the nucleic acid sequences that encode them. Also disclosed are antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of apoptosis associated disorders involving these novel human nucleic acids and proteins.

Method of treating apoptosis and compositions thereof

Growing community of inventors

Weston, MA, United States of America

Stanley J Korsmeyer