Genetics Institute, Inc.

The General Hospital Corporation

Other

Wyeth

The Wistar Institute

Stanley F Wolf

Gordon G Wong

Steven C Clark

Rodney M Hewick

Giorgio Trinchieri

Bice Perussia

Michiko Kobayashi

Megan Sykes

Margot O'Toole

Knut Sturmhoefel

This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.

Natural killer stimulatory factor

Methods of enhancing immune responses in which soluble forms of costimulatory molecules, e.g., B7 molecules, are administered to augment immune responses to antigens, e.g., to tumor cells and infectious agents are provided. The subject methods are useful for both prophylactic and therapeutic immunization of subjects.

Enhancing immune responses with B7-1 or B7-2 in the absence of a crosslinking agent

A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.

Antibodies to natural killer stimulatory factor

The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed. In other embodiments, graft-vs. leukemia effects are maintained or promoted.

Use of interleukin-12 to prevent graft versus host disease

Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.

Methods of inducing gamma interferon and stimulating blood cell

Natural killer cell stimulatory factor

The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed.

Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.

Growing community of inventors

Arlington, MA, United States of America

Stanley F Wolf