Photopharmica Limited

Stanley Beames Brown

John Griffiths

Cassandra Claire O'Grady

David Ian Vernon

Kirste Joanne Mellish

Andrea Lucille Bell

Jack Schofield

Cassandra Clare O'Grady

Richard George Tunstall

David John Howard Roberts

The present invention relates to a composition which includes a moiety of formula 

Biologically active methylene blue derivatives

The present invention relates to a method of photodynamic therapy and to a method of inducing a photocytoxic effect which comprises applying to an area to be treated an effective amount of a compound of formula in which R, R, Rand Reach independently is an optionally -substituted linear, branched or cyclic hydrocarbon group, or Rand Rtogether with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring or Rand Rtogether with the N atom to which they are attached form an optionally substituted 5-, 6- or 7- membered ring;

A phenothiazinium compound of Formula (I) wherein: 

The present invention relates to a pharmaceutical composition which contains a compound of formula in which R, R, Rand Rare each n-butyl, where Xis a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant.

A phenothiazinium compound, compositions and medicaments for use in promoting wound healing and a method for promoting wound healing or cosmetic use by applying or administering a phenothiazinium compound of Formula (1) to a wound site or the skin, and optionally exposing the wound site or skin to light.

Wound healing

A phenothiazinium compound of Formula (I): wherein: in which R' and R&#x2033; each independently is a linear, branched or cyclic hydrocarbon group, or R&#x2032; and R&#x2033; together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring;

A compound for use as a photosensitiser in PDT, in photochemical internalisation in the production of a cancer vaccine or in the diagnosis or detection of medical conditions, the compound having a photosensitising chromophoric system, a sulphonamido functionality and a carboxy functionality. The compounds used in the present invention are photosensitisers in PDT in vivo, and show phototoxic activity in vitro. The compounds are used to treat pre-cancerous conditions, cancer, ophthalmological disease, vascular problems, arteriosclerosis and restenosis and autoimmune diseases, skin diseases and other benign conditions, and for anti-microbial treatments.

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Burley-in-Wharfedale, United Kingdom

Stanley Beames Brown