Spofa, Spojene Podniky Pro Zdravotnickou Vyrobu

Stanislava Pokorna

Jiri Krepelka

Milan Melka

Ruzena Reichlova

Jaroslava Grimova

Karel Rezabek

Antonin Cerny

Irena Kejhova

Milan Miko

Vojtech Pujman

Iva Vancurova

Slavjanka Cernochova

Marta Beitova

6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, ##STR1## in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The subject compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently have great potential for the treatment of malignant neoplastic diseases in mammals.

6-purinyl N-/2-chloroethyl/carbamate and thiocarbamate and process for

Basic ethers of 7-oxo-7H-benzo(c) fluorene have been shown to evidence a pronounced antineoplastic and immunosuppressive effect in mammals suffering from leukemia. The technique for preparing the described ethers and the addition salts thereof with pharmaceutically acceptable organic and inorganic acids involves the aminoalkylation of 5-hydroxy-7-oxo-7H-benzo(c) fluorene and its corresponding nuclear substituted derivatives on the hydroxylic oxygen atom.

Basic ethers of 7-oxo-7H-benzo(c) fluorene and a process for their

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Prague, Czechia

Stanislava Pokorna