Zentiva K.s.

Stanislav Radl

Jindrich Richter

Ludek Ridvan

Tomas Pekarek

Kamal Jarrah

Monika Zatopkova

Lukas Krejcik

Josef Cinibulk

Petr Hruby

Hana Brusova

Natalia Csokova

Anna Zerzanova

Michal Voslar

Robert Klvana

Jan Stach

Ales Halama

Ivo Strelec

Pavel Zvatora

Stanislav Man

Ondrej Klecan

Ondrej Pisa

Kristyna Benediktova

Martin Stefko

Lucie Krumbholcova

The new method of preparing 1-(2-(2,4-di-methylphenylsulphanyl)phenyl)piperazine of formula (I) or its salt comprises a reaction of 2-(2,4-dimethylphenyl-sulphanyl)benzeneamine of formula (XI), wherein Me is methyl, with a suitable precursor of formation of piperazine ring of formula (XII), wherein LG is a leaving group and R is hydrogen or a protective group, in a suitable organic solvent, wherein the reaction is carried out without presence of a base in a neutral or acidic environment. (Formulae (I), (XI), (XII)) 

Method of preparing vortioxetine

The invention deals with new salts of the desvenlafaxine base of formula (I) with oxalic acid, the new salts being the hydrogen oxalate of formula (II) in the proportion of desvenlafaxine:oxalic acid of 1:1 and hemioxalate of formula (III) in the proportion of desvenlafaxine:oxalic acid of 2:1. 

Salts of desvenlafaxine and a method of their preparation

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Kvetnice, Czechia

Stanislav Radl