Bayer Aktiengesellschaft

Hoffmann-La Roche Inc.

Bayer Akt.

Stanislav Kazda

Andreas Knorr

Stefan Wohlfeil

Martin Beuck

Rudolf H Hanko

Johannes-Peter Stasch

Peter Fey

Thomas Kramer

Walter Hubsch

Ulrich E Muller

Matthias Muller-Gliemann

Jurgen Dressel

Egbert Wehinger

Siegfried Zaiss

Horst Meyer

Friedrich Bossert

Kurt Stoepel

Arend Heise

Wulf Vater

Robertson Towart

Ozkan Yalkinoglu

Hilmar Bischoff

Dirk Denzer

Bernward Garthoff

Ulrich Niewohner

Claudia Hirth-Dietrich

Matthias M uller-Gliemann

Ulrich E M Uller

J Urgen Dressel

Gerhard Franckowiak

Eckhard Schwenner

Thomas Kr Amer

Walter H Ubsch

Friedrich Hoffmeister

Klaus Schlossmann

Matthias Schramm

Siegfried Raddatz

Arno Widdig

Hans-Joachim Kabbe

Michael Matzke

Gunter Thomas

Klaus Mohrs

Hartmut Stegelmeier

Siegfried Goldmann

Rainer Gross

Bodo Junge

Jurgen Stoltefuss

Harald Horstmann

Horst Boshagen

Bernd Klinksiek

Peter Serno

Helmut Heitzer

Michael Kayser

Gunther Kinast

Karl Heinrich Mayer

Alfred Zembrod

Rudolf Hiltmann

Gerhard Schluter

Ulrich Posanski

Fridolin Hefti

Marcel Gerold

Friedrich Bosseret

Walter Husch

Hans-Peter Belleman

Hans-Peter Bellemann

Hartmut Stagelmeier

Wolfgang Seidel

Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.

Trisubstituted biphenyls

Heterotricyclically substituted phenyl-cyclohexanecarboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid

The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.

Heterocyclically substituted phenylacetic acid derivatives and their use

Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.

Substituted pyridines and 2-oxo-1,2-dihydropyridines

Heterotricyclically substituted phenyl-cyclohexane-carboxylic acid derivatives are prepared by reacting the heterocyclic compounds with cyclohexanecarboxylic acid derivatives which are substituted by benzyl halide radicals. The compounds can be employed as active compounds in medicaments.

Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be prepared by reacting sulphonylbenzyl-substituted aldehydes with appropriate CH-acidic compounds and then dehydrating. The sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives can be used in medicaments, in particular for the treatment of high blood pressure and atherosclerosis.

Sulphonylbenzyl-substituted imidazolylpropenoic acid derivatives

Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.

Substituted biphenylpyridones

Antihypertensive and antiatherosclerotic trisubstituted biphenyls of the formula ##STR1## in which R.sub.1 represents a carboxyl radical or represents a C.sub.1 -C.sub.8 -alkoxycarbonyl radical,

The substituted monopyridyl and bipyridyl derivatives are prepared by reacting substituted pyridine halides with phenylboronic acids. They are suitable for use as active compounds in medicaments for treating arterial hypertension and atherosclerosis.

Substituted monopyridylmethyl derivatives

Phenylglycinamides of heterocyclically substituted phenylacetic acid derivatives are prepared by reacting phenylacetic acids with glycinamides. The compounds can be used as active compounds in medicaments.

Phenylglycinamides of heterocyclically substitued phenylacetic acid

Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.

Substituted 2,4-imidazolidinediones

Substituted imidazo[4,5-b]pyridines and benzimidazoles are prepared by reacting imidazo[4,5-b]pyridines or benzimidazoles with appropriately substituted benzyl halides. The substituted imidazo[4,5-b]pyridines or benzimidazoles can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.

Substituted imidazo[4,5-b]pyridines and benzimidazoles

The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.

Imidazolyl-substituted cyclohexane derivatives are prepared by reacting appropriate cyclohexane derivatives with substituted imidazoles and subsequent variation of the substituents. The imidazolyl-substituted cyclohexane derivatives can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.

Imidazolyl-substituted cyclohexane derivatives

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Wuppertal, Germany

Stanislav Kazda