Institut National De La Sante Et De La Recherche Medicale

Institut Pasteur

Institut National De La Recherche Agronomique

Enterome

Novo Nordisk A/s

Assistance Publique-hopitaux De Paris

Université Pierre Et Marie Curie

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Institut De Recherche Pour Le Developpement

Stanislav Ehrlich

Matthieu Pichaud

Pierre Rimbaud

Emmanuelle Le Chatelier

Karine Clement

Jean-Daniel Zucker

This invention is related to the area of characterization of inflammation in relation with the gut microbiota, in metabolic and autoimmune disorders. In particular, it relates to the identification of gene signatures which can be used as a marker predictive of inflammation associated diseases, such as liver-related metabolic disorders, in particular to the evolution of benign steatosis towards its most severe forms (steatohepatitis and cirrhosis) or autoimmune disorders, in particular inflammatory bowel diseases (Crohn's and Ulcerative Colitis). These gene signatures can therefore be used as a means of diagnosis, prognosis, stratification for drug studies, for monitoring patient and for assigning an appropriate treatment.

Gene signatures of inflammatory disorders that relate to the liver

Growing community of inventors

Orsay, France

Stanislav Ehrlich