Biophytis

Sorbonne Université

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Université Pierre Et Marie Curie

Institut Biophytis Sas

Université Paris 6 Pierre Et Marie Curie

Institut National De La Recherche Agronomique

Inserm

Stanislas Veillet

René Lafont

Jose-Alain Sahel

Mathilde Latil

Waly Dioh

Pierre Dilda

Franck F Lepifre

Sophie N Raynal

Jean-Denis Durand

Pierre-Paul Elena

Valerie Fontaine

Valérie Fontaine

Elodie Monteiro

Laurence Dinan

Christine Balducci

Louis Guibout

Serge Camelo

Onnik Agbulut

Maria Serova

Karine Clement

Anne-sophie Foucault

Susanna Del Signore

Philippe Dupont

Salwa Rizkalla

José-Alain Sahel

Annie Quignard-BoulangÉ

Franck Lepifre

Lafont René

Disclosed are 20-hydroxyecdysone and the derivatives thereof, intended for use in the treatment of a neuromuscular disease such as spinal muscular atrophy or amyotrophic lateral sclerosis, or more particularly in the treatment of a specific disorder of the motor neurons causing alterations in the muscular function occurring in the context of these neuromuscular diseases.

Phytoecdysones and the derivatives thereof for use in the treatment of neuromuscular diseases

Disclosed is chemical compounds C that are derivatives of norbixin and have tropism for the eye, and are intended to be used in the treatment of eye diseases in mammals, in particular in the context of altering the retinal pigment epithelium and more particularly in the context of age-related macular degeneration (AMD) and Stargardt's disease.

Chemical compounds targeting the eye and use thereof in the treatment of eye diseases

The invention relates to 20-hydroxyecdysone and the derivatives thereof, for use in the treatment of genetic myopathies.

Use of 20-hydroxyecdysone and the derivatives thereof in the treatment of myopathies

Disclosed is a method for the treatment, prevention and/or stabilisation of ARMD, Stargardt disease, pigmentary retinopathy and/or diabetic retinopathy, including the application of a 3-deoxyanthocyanidin of formula (I) in which R, R, R, R, R, R, R, R, R, R, Rand Xare as defined, with the condition that at least one of R, R, R, Ror Ris a hydroxyl and at least one of R, R, Ror Ris a hydroxyl.

Use of 3-deoxyanthocyanidins for treating occular diseases

Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular quality in sarcopenic mammals and treating and/or preventing sarcopenia using the chemical compounds and, in particular, sarcopenic obesity and the associated complications and/or pathologies thereof, such as loss of strength, muscle mass, performance and of physical and movement capacity. Also, a method of improving muscle quality in obese mammals and treating and/or preventing of obesity and associated complications and/or pathologies, advantageously type 2 diabetes and metabolic syndrome, using the chemical compounds.

Chemical compounds and use thereof for improving muscular quality

A method of photoprotecting cells of the retinal pigment epithelium (EPR) in mammals using a composition having norbixin. The norbixin is produced by purification from an extract ofseeds.

Composition containing norbixin for protecting cells of the retinal pigment epithelium

The invention relates to the use of norbixin and an urucum extract enriched in bixin and/or norbixin as a food. The invention also provides a food preparation comprising norbixin, bixin or an extract comprising at least bixin or norbixin, the preparation being intended to be administered orally, for the protection of mammalian skin against UV-radiation.

Preparation for sun protection

For reducing the negative effects of the metabolic syndrome on mammal organisms, it is proposed to use phytoecdysones for diminishing the fat body mass in individuals, notably with a weight excess. Phytoecdysones are advantageously incorporated into a food composition. The phytoecdysones can come from food plants, such as quinoa.

Use of phytoecdysones in the preparation of a composition for acting on the metabolic syndrome

Growing community of inventors

Savigny sur Orge, France

Stanislas Veillet