Instytut Chemii Bioorganicznej Pan

Uniwersytet Medyczny Im. Karola Marcinkowskiego

Bioinfobank Sp. Z O. O.

Stanisaw Nowak

Eliza Wyszko

Jan Barciszewski

Leszek Rychlewski

Katarzyna Rolle

Miroslawa Barciszewska

Iwona Gawronska

Ryszard Zukiel

The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.

Sequence of dsRNA: ATN-RNA specific for tenascin-C

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Poznan, Poland

Stanisaw Nowak