Schering Corporation

Hoffmann-la Roche Inc.

Evrys Bio, LLC

Novartis Ag

F. Hoffmann-la Roche Ag

Schering-plough Corporation

Stacy W Remiszewski

Ronald J Doll

F George Njoroge

Arthur G Taveras

Alan K Mallams

John J Piwinski

Ronald L Wolin

Joanne M Petrin

W Robert Bishop

Carmen S Alvarez

Tarik Lalwani

Qun Sun

Yan Lou

Lillian Chiang

Joseph Michael Kelly

Richard William Versace

Robert Francis Kester

Lawrence Blas Perez

Michael Alan Green

Kang Le

Kenneth Walter Bair

Christophe Michoud

Sushil Kumar Sharma

Andrew Forrest Donnell

Kenneth Carey Rupert

Lidia Cristina Sambucetti

Emre Koyuncu

Frank Kayser

Steven Gregory Mischke

Weiya Yun

Joan Heather Hogg

Sarah Jocelyn Fink

Xiaochun Han

Eain Anthony Murphy

Robert W Bishop

Adriano Afonso

Dinanath F Rane

Norman Kong

Shaoqing Chen

John Anthony Moliterni

Martin Weisel

John Anthony

Novel thiazole- and isoquinoline-containing compounds are presented that are useful for treating and/or preventing broad-spectrum viral infections. Methods of treating and/or preventing broad-spectrum viral infections are also presented. These compounds have shown inhibition of HCMV, influenza viruses, Zika virus, BK Virus and RSV replication in cell-based assays.

Broad spectrum antiviral compositions and methods

Novel compounds useful for treating and/or preventing HCMV infections are provided.

Anti-HCMV compositions and methods

This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.

Disclosed are compounds of Formula I, or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R, R, R, Rand Rare as described in this application, and methods of using said compounds in the treatment of cancer. 

Tetrahydro-benzodiazepinones

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, X, Y, Z, R, R, Rand Rare described in this application, and methods of using said compounds in the treatment of cancer. 

Antiproliferative benzo [B] azepin-2-ones

Disclosed are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R1, R2, R3, R4 and R5 are described herein, and methods of using said compounds in the treatment of cancer. 

2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein R, R, R, m, n and q are described in this application, and methods of using said compounds in the treatment of cancer. 

Azaheterocycles as BIR2 and/or BIR3 inhibitors

Disclosed are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein W, Y, Z, R, R, Rand Rare as described in this application, and methods of using said compounds in the treatment of cancer. 

Indolines

There are provided compounds of the formula 

Substituted hetero-azepinones

The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.

Deacetylase inhibitors

Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.

N-substituted urea inhibitors of farnesyl-protein transferase

Compounds for the inhibition of farnesyl protein transferase

Growing community of inventors

Washington Township, NJ, United States of America

Stacy W Remiszewski