Valencia Technologies Corporation

Valencia Bioscience, Inc.

Stacy Greiner Chambliss

David K L Peterson

Jeffrey H Greiner

Chuladatta Thenuwara

A method of treating osteoarthritis includes an implantable stimulator generating stimulation sessions at a duty cycle that is less than 0.05 and applying the stimulation sessions by way of the central electrode and the annular electrode to a location within a patient that includes at least one of an acupoint labeled ST35, an acupoint labeled EX-LE-4, or a location on a line that intersects the acupoints labeled ST35 and EX-LE-4.

Methods and systems for treating osteoarthritis using an implantable stimulator

A method comprises generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator, the stimulation sessions to a patient. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery having an internal impedance greater than 5 ohms.

Implantable electroacupuncture system and method

A method comprises generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator, the stimulation sessions to a patient. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes.

A method of treating osteoarthritis in a knee includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a location that includes at least one of an acupoint labeled ST35, an acupoint labeled EX-LE-4, and a location on a line that intersects the acupoints labeled ST35 and EX-LE-4. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.

An exemplary method treating a chronic low back pain condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to a target tissue location within the patient by way of an electrode array located within the patient at an acupoint corresponding to the target tissue location.

Methods and systems for treating a chronic low back pain condition using an implantable electroacupuncture device

An exemplary electroacupuncture device may be implanted beneath a skin surface of a patient at a location corresponding to a joint affected by osteoarthritis and may perform methods for treating the osteoarthritis. In some implementations, the electroacupuncture device is powered by a primary battery located within the electroacupuncture device and having an internal impedance greater than 5 ohms and a capacity of less than 60 milliamp-hours (mAh).

Methods and systems for treating osteoarthritis using an implantable electroacupuncture device

A method of treating a mental disorder of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at or near an acupoint corresponding to at least one of a trigeminal nerve and an occipital nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device, the stimulation sessions to at least one of the trigeminal nerve and the occipital nerve by way a central electrode and an annular electrode located on the electroacupuncture device in accordance with the duty cycle.

Implantable electroacupuncture system and method for treating depression and similar mental conditions

An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of a saphenous nerve and a peroneal nerve of the patient by way of an electrode array located within the patient at an acupoint corresponding to at least one of the saphenous nerve and the peroneal nerve.

Implantable electroacupuncture system and method for treating dyslipidemia and obesity

An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD includes an IEAD housing having an electrode configuration thereon that includes at least two electrodes, and pulse generation circuitry located within the IEAD housing and electrically coupled to the at least two electrodes. The pulse generation circuitry is adapted to deliver EA stimulation pulses to the patient's body tissue at or near the target tissue location in accordance with a specified stimulation regimen, the stimulation regimen requiring that the stimulation session have a duration of Tminutes and a rate of occurrence of once every Tminutes, and wherein a ratio of T/Tis no greater than 0.05.

Implantable electroacupuncture device and method for treating erectile dysfunction

An exemplary method of treating a chronic low back pain condition in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at at least one of acupoints BL22, BL23, BL24, BL25, and BL26 within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of Tto Tand each stimulation session included in the stimulation sessions has a duration of Tminutes and occurs at a rate of once every Tminutes, and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location in accordance with the duty cycle.

An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied to at least one of the acupoints on the chorea line. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device and a conduit extending therefrom. At least one electrode is located on the outside of the housing. At least one electrode is located at an opening formed through the conduit. The housing contains a primary power source and pulse generation circuitry. A sensor wirelessly senses externally-generated operating commands, such as ON, OFF and AMPLITUDE. The pulse generation circuitry generates stimulation pulses. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen.

Implantable electroacupuncture system and method for treating parkinson's disease and essential tremor through application of stimului at or near an acupoint on the chorea line

An exemplary method of treating obesity or dyslipidemia of a patient using a small implantable electroacupuncture device (IEAD) includes 1) implanting the IEAD below the skin surface of the patient at or near a target tissue location selected from the group of target tissue locations comprising acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, LR8 and their underlying nerves, the saphenous nerve and the peroneal nerve, and 2) enabling the IEAD to provide EA stimulation pulses in accordance with a stimulation regimen that provides a stimulation session having a duration of T3 minutes at a rate of once every T4 minutes, where the ratio of T3/T4 is no greater than 0.05, and wherein T3 is at least 10 minutes and no greater than 60 minutes.

An exemplary method of treating obesity or dyslipidemia of a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to at least one of a saphenous nerve and a peroneal nerve of the patient, stimulation sessions at a duty cycle that is less than 0.05, and 2) applying, by the electroacupuncture device in accordance with the duty cycle, the stimulation sessions to at least one of the saphenous nerve and the peroneal nerve by way of a central electrode and an annular electrode located on a housing of the electroacupuncture device.

An implantable electroacupuncture device (IEAD) treats Parkinson's disease or Essential Tremor through application of stimulation pulses applied at at least one of acupoints GB34 and GV20. The IEAD includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.

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Valencia, CA, United States of America

Stacy Greiner Chambliss