Editas Medicine, Inc.

Stacy Capehart

Sam Saccomano

Karin Zemski Berry

Bruce Eaton

Chemical syntheses of guide molecules are disclosed, along with compositions and methods relating thereto. A cost-effective and straightforward chemical synthesis of high-purity unimolecular guide molecules with minimal n−1 and/or n+1 species, truncation species, and other contaminants by providing, among other things, methods for synthesizing unimolecular guide molecules that involve cross-linking two or more pre-annealed guide fragments.

Growing community of inventors

Boulder, CO, United States of America

Stacy Capehart