Other

Merck + Co., Inc.

Merck Frosst Canada, Inc.

Stacia Kargman

Thomas J Simon

Jilly Evans

Gary P O'Neill

Philip J Vickers

Jillian F Evans

This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.

Method of treating colonic adenomas

This invention discloses novel immunogenic peptide sequences, derived from the human cyclooxygenase-1 and cyclooxygenase-2 cDNAs which elicit specific non cross-reactive antibody responses. Assays are also disclosed for selectively and independently detecting cyclooxygenase-1 or cyclooxygenase-2 proteins present in a given biological sample.

Peptide sequences and antipeptide antisera for detecting human

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Hampstead, Canada

Stacia Kargman