Baxter International Inc.

Stacey S Thompson

James P McShane

Ray W Wood

Joseph C Wong

Rao Chilamkurti

Norma Stephens

Mary Samuel

The present invention provides a premixed form of a buffered piperacillin product having a near neutral pH and capable of a shelf life of at least nine months, with freezer storage (&minus;20&deg; C. or lower), or a refrigerated shelf life of up to 14 days at about 5&deg; C. The piperacillin may additionally contain a tazobactam component to inactivate beta-lactamases that commonly cause resistance to penicillins, allowing the piperacillin component to destroy susceptible bacteria. With the addition of dextrose, the premixed composition is physiologically isosmotic.

Premixed formulation of piperacillin sodium and tazobactam sodium injection

A receptacle (500) is provided for coupling an adaptor (10) having a vial (54) including a beneficial agent to an IV administration set (526). In an embodiment, the receptacle (500) includes an injection site (512) for receiving a cannula (26) from the adaptor (10). A resilient divider (516) separates the receptacle (500) into two sections defined by an upper fitment (508) and a lower fitment (510). A container (520) holding a solution is in fluid communication with the receptacle (500) via an inlet (502). A through bore (518) allows the solution from the container (520) to pass through the resilient divider (516) when the adaptor (10) is removed from the receptacle (500).

In-line drug delivery device for use with a standard IV administration

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Wheeling, IL, United States of America

Stacey S Thompson