Blaze Bioscience, Inc.

Stacey J Hansen

Julia E Novak

Scott R Presnell

Mark R Stroud

Natalie Winblade Nairn

Dennis M Miller

Claudia Jochheim

Valorie R Wiss

Kelly Byrnes-Blake

Compositions and formulations comprising chlorotoxin conjugate compounds are provided, including native and modified variants of chlorotoxin peptide conjugated to detectable agents or active agents. Methods of detecting and treating ductal carcinoma in situ breast cancer, invasive ductal carcinoma breast cancer, lobular carcinoma in situ, invasive lobular carcinoma, and triple-negative breast cancer with chlorotoxin conjugate compounds are also provided, including methods of imaging tumor tissues and cells.

Methods of treating breast cancer

Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or bind to the cartilage or kidney of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an active agent to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures, or cells targeted by the peptide.

Tissue-homing peptide conjugates and methods of use thereof

Growing community of inventors

Renton, WA, United States of America

Stacey J Hansen