Vanderbilt University

The Hospital for Sick Children

Stacey A Seeback

Roman Alexander Melnyk

Dana Borden Lacy

John Tam

Nicole M Chumbler

Zhifen Zhang

is a leading cause of antibiotic-associated infection in hospitals worldwide. There is a need for a vaccine tothat can target toxic proteins, or that can elicit adequate immunity to prevent infection or reduce the severity of infection. Modifiedtoxin A and B (TcdA and TcdB) proteins are described herein, which comprise mutations that reduce toxin A and B toxicity compared to the native toxin. The proteins described are highly similar to the native toxin of, but toxicity is reduced.

Growing community of inventors

Greenbrier, TN, United States of America

Stacey A Seeback