Korea University Research and Business Foundation

Konkuk University Industrial Cooperation Corp

Amolifescience Co., Ltd.

Konkuk University Industry-Academic Cooperation Foundation

Ssang-Goo Cho

Chan Kim

In Yong Seo

Song Hee Koo

Dong-Sik Seo

Hui-Gwan Goo

Kyuwon Baek

Seonho Jang

Kyung Min Lim

Sang-eun Park

Gwang-Mo Yang

Jihye Won

Chulbae Yoo

Aram Chung

Geunho Kang

Soobin Jang

The present invention relates to a method of inhibiting, delaying, or reversing cellular senescence that includes having an isolated cell flow through a microchannel, and crashing the cell in flow into an impact surface installed on a flow path of the cell to apply a physical impact to the cell, resulting in inhibiting, delaying, or reversing senescence of the cell, while maintaining high biological activity, and in particular, it relates to a method that can further increase the value of a stem cell as a therapeutic cell for various degenerative diseases by maintaining undifferentiated state of the stem cell even during a long-term culture period to maintain multipotency, and to the cells obtained by the method.

Microfluidic system, method for inhibiting, delaying, or reversing cellular senescence using microfluidic system, and cell obtained therefrom

This disclosure provides for a three-dimensional (3D) microenvironment presenting defined physical or mechanical cues that regulate cellular behavior and use of the matrix. The disclosure also provides for devices and methods for screening for optimal combinations of physical and mechanical cues in order to create a microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation.

Defined three-dimensional microenvironment for stem cell

Growing community of inventors

Seoul, South Korea

Ssang-Goo Cho