Suven Life Sciences Limited

Suven Life Science Limited

Sriramachandra Murthy Patnala

Venkateswarlu Jasti

Ramakrishna Nirogi

Jyothsna Ravula

Anil Karbhari Shinde

Abdul Rasheed Mohammed

Pradeep Jayarajan

Gopinadh Bhyrapuneni

Ishtiyaque Ahmad

Ramasastri Kambhampati

Srinivasa Rao Ravella

Suresh Yarlagadda

Praveen Kumar Roayapalley

Rama Sastri Kambhampati

Nagaraj Vishwottam Kandikere

Reddy Muddukrishna Chillakur

Ramkumar Subramaniam

Reddy Venkat Mekala

Ishtiyaque Ahmed

The present invention relates to novel compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them.  The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to 5-HTreceptors.

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The present invention relates to novel 1,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them.  The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.

The present invention provides novel functional assay for 5-HT, histamine H1 or adrenergic alpha 1b receptors, by measuring intracellular cyclic adenosine monophosphate (cAMP) levels utilizing reporter gene driven cell based assay. The novel assay provides both binding affinity as well as mode of action of compounds in a single set. The novel assay of the invention is useful in identification of compounds acting through 5-HT, histamine H1 or adrenergic alpha 1b receptors. Furthermore, the assay offers utility in categorizing compounds in to agonist, partial agonist, inverse agonist and antagonist classes. The novel assay can be scaled up to any high throughput format.

Functional assay for 5-HT2A, histamine H1 or adrenergic alpha 1B receptors

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Hyderabad Telangana, India

Sriramachandra Murthy Patnala