Jounce Therapeutics, Inc.

Codiak Biosciences, Inc.

Lonza Sales Ag

Sriram Sathyanarayanan

Douglas E Williams

John D Kulman

Ke Xu

Stephen Sazinsky

Jennifer S Michaelson

Kutlu Goksu Elpek

Shelly Martin

Nuruddeen D Lewis

Yu Zhou

Leonid A Gaydukov

Tatiana Novobrantseva

Christopher Harvey

Virna F Cortez-Retamozo

Heather Hirsch

Amit Deshpande

Lauren Pepper MacKenzie

Dalia Burzyn

Adam Thomas Boutin

Sushrut Kamerkar

Igor Feldman

Jason Windham Reeves

Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.

Exosomes for immuno-oncology and anti-inflammatory therapy

Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages. In certain embodiments, disclosed herein are methods and compositions for increasing macrophage polarization for the treatment of cancer.

Methods and compositions for macrophage polarization

Gene expression signatures correlating to ICOS expression levels are provided. Methods of treatment comprising determining ICOS expression levels using gene signatures in patients and administering anti-ICOS antibodies are also provided.

Gene signatures for determining ICOS expression

Provided herein are embodiments relating to therapeutic applications of B7-H4 antibodies.

Methods of treating conditions with antibodies that bind B7-H4

Provided herein are various embodiments relating to antibodies. Some of the embodiments include agonist antibodies that bind ICOS. Such antibodies can be used in methods to treat, for example, cancer.

Antibodies to ICOS

Growing community of inventors

Lexington, MA, United States of America

Sriram Sathyanarayanan