Shilpa Medicare Limited

Shilpa Meicare Limited

Sriram Rampalli

Lav Kumar Upalla

Prashant Purohit

Gopala Krishna Dasari

Chanti Babu Patneedi

Akshay Kant Chaturvedi

Chaturvedi Akshay Kant

Krishna Kumar Ramachandrula

Mohanrao Seshagiri Vijaya Murali

Suryanarayan Cherukuvada

Vijaya Murali Mohan Rao Seshagiri

Lavkumar Upalla

Pradeep Pothana

The present invention relates to novel crystalline and amorphous polymorphic forms of Ribociclib(1) mono succinate. (I) Said crystalline forms may be useful in the improved preparation of oral dosage forms for the treatment of cancer. 

Polymorphs of Ribociclib mono succinate

The present invention relates to a process for the preparation of 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib of Formula (I).  The present invention further relates to a process for the preparation highly pure 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one or Ibrutinib(I).

Process for the preparation of ibrutinib

The present invention relates to a process for the preparation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I).  The present invention further relates to a process for the purification of 4-[4-({[4-chloro-3-(trifluoromethyl) phenyl] carbamoyl} amino)-3-fluorophenoxy]-N-methylpyridine-2-carboxamide or Regorafenib (I) to provide highly pure material. The present invention further relates to a process for the preparation stable crystalline material of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-N-methyl pyridine-2-carboxamide or Regorafenib (I) useful in the preparation of pharmaceutical compositions for the treatment of cancer.

Process for the preparation of regorafenib and its crystalline forms

The present invention relates to an improved process for preparation of Dasatinib monohydrate Formula A, comprising the steps of: 

Process for preparing dasatinib monohydrate

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Vizianagaram, India

Sriram Rampalli