Cisco Technology, Inc.

Agency for Science, Technology and Research

Carterra, Inc.

Ethicon, Gmbh

University of Utah Research Foundation

Depuy Synthes Products, Inc.

Ethicon Endo-surgery, Inc.

Johnson and Johnson Vision Care, Inc.

Mentor Worldwide LLC

Wasatch Microfluidics, LLC

Endo-surgery, Inc.

Sriram Natarajan

Kevin L Cooper

Bruce Kent Gale

Hong Yee Low

Murty Narayan Vyakarnam

Isabel Rodriguez

Chee Tiong Lim

Sharat C Prasad

Joshua Wayne Eckman

Audrey Yoke Yee Ho

Yu Deng

Mark Eddings

Noha Elmouelhi

Adam Miles

David Myszka

Emma Kim Luong-Van

Joseph J Hammer

Yanfeng Wang

David A Chang-Yen

Jim Smith

Josh Eckman

Randall Braxton Pugh

Zohra Fadli

Michael Hoffman

Gary Chan

Jayakrishna M Menon

James Smith

Hector Javier Toro Estrella

Christopher Morrow

Annmarie Mullen

Isabel Rodriquez

Gary K Chan

Prasad Sharat

Hector Toro Estrella

A method of making a self-sealing membrane for a prosthetic implant includes applying tension to a first layer of a cured elastomeric material to stretch the first layer, and while the first layer remains stretched, applying a second layer of an uncured elastomeric material over a first major surface of the first layer. After the second layer is cured, the tension on the first layer is released, whereupon the first layer returns to a non-stretched configuration for holding the second layer in contraction. The method includes, while the first layer remains stretched, applying a third layer of an uncured elastomeric material over a second major surface of the first layer. After curing the second and third layers, tension is released from the first layer, which returns to the non-stretched configuration for holding the second and third layers in contraction.

Systems, devices and methods of making prosthetic implants having self-sealing membranes for closing punctures and preventing leaks

The present disclosure provides apparatuses, systems, and methods involving a spotter for depositing a substance on a submerged surface. The spotter comprises an outlet cavity defined at least in part by a spotting orifice, a first opening, and a second opening. The spotter also comprises a first conduit fluidly coupled to the first opening and a second conduit fluidly coupled to the second opening. The spotter is adapted so that fluid flowing through the first conduit and the second conduit is communicated among the first opening, the second opening, and a submerged deposition surface when the sealing orifice is sealed against the submerged deposition surface to form a deposition spot on the submerged deposition surface. The submerged deposition surface is within a liquid such that the liquid covers the deposition spot upon removal of the orifice from the deposition surface.

Method and device for depositing a substance on a submerged surface

The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array. The spotter apparatus includes a loading surface, including a first well and a second well, and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

Tip overlay for continuous flow spotting apparatus

An implant having an adhesive structure comprising a planar surface having two sides and rectangular cuboid-based protrusions having pyramidal tips extending from at least one of said sides, optionally having a porous basic supporting structure, and methods of making and using such implants.

Adhesive structure with tissue piercing protrusions on its surface

The present disclosure provides apparatuses, systems, and methods involving a spotter apparatus for depositing a substance from a carrier fluid onto a deposition surface in an ordered array, the spotter apparatus comprising a loading surface including a first well and a second well; and a different outlet surface, including a first opening and a second opening, where a first microconduit fluidly couples the first well with the first opening and a second microconduit fluidly couples the second well with the second opening. An overlay is sealed to the outlet surface and penetrated by a deposition channel that is situated to communicate carrier fluid among the first opening, the second opening, and the deposition surface when the overlay is pressed against the deposition surface.

A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 &#x3bc;m to about 3 &#x3bc;m, and heights from about 2 &#x3bc;m to about 20 &#x3bc;m from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.

Super-hydrophilic structures

This invention discloses methods and apparatus for providing an ophthalmic lens with a textured pattern within an optic zone and an ophthalmic lens with a textured pattern within the optic zone.

Surface enhanced ophthalmic lens

A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

Adhesive structure with stiff protrusions on adhesive surface

Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on, a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.

Microfluidic interface for highly parallel addressing of sensing arrays

A blood clotting substrate and device which has a plurality of oxygen plasma-treated polypropylene pillars extending from the surface of a polypropylene film.

Blood clotting substrate and medical device

Synthetic polymer substrates comprising a hierarchical surface structure of multiple domes and multiple pillars on said domes, wherein said substrate is a synthetic polymer film, said domes have diameters in the range from about 5 &#x3bc;m to about 400 &#x3bc;m, heights in the range from about 2.5 &#x3bc;m and about 500 &#x3bc;m, and said pillars have diameters in the range from about 20 nm to about 5 &#x3bc;m and aspect ratios of from about 2 to about 50, and methods of making and using them.

Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them

Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.

Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.

Microassay with internal referencing

A method for negotiating speed between a Fiber Channel (FC) local client and a remote FC client across a DWDM network is provided. A transmission speed of the local FC client at a local ingress transport interface is detected. The data from the local FC client is forwarded along with the detected transmission speed to a remote egress transport interface. The remote egress interface forwards the data at the detected transmission speed to the remote FC client. The present invention eliminates complex speed negotiation state machines that would otherwise be required to make the DWDM transport behave like a virtual wire with respect to the FC ports and to allow the FC clients to negotiate the desired speed directly between themselves.

Simple fibre channel speed negotiation across transport

The link status of a Fibre-Channel link interconnecting two Fibre-Channel ports may be determined by a third entity distinct from the two Fibre-Channel ports. The third entity may be a transport interface used to connect one of the Fibre-Channel ports to a transport network that carries the link. The transport interface may also learn the Fibre-Channel port types of the two ports.

Growing community of inventors

Hillsborough, NJ, United States of America

Sriram Natarajan