Sun Pharmaceutical Industries Limited

Sun Pharma Advanced Research Company Limited

Srinivasu Kilaru

Rajamannar Thennati

Nileshkumar Sureshbhai Patel

Muthukumaran Natarajan

Dwivedi Shriprakash Dhar

Mehul Chandrakatbhai Bhatt

Macwan Valance Surendrakumar

Ashok Punju Borase

The present invention provides novel salts of nilotinib and polymorphs thereof. The acid addition salts of nilotinib with benzenesulfonic acid, butanedisulfonic acid, 1-5-naphthalenedisulfonic acid, naphthalene-1-sulfonic acid and 1-hydroxynaph-thoic acid; hydrates and anhydrates thereof.

Salts of nilotinib and polymorphs thereof

The present invention relates to an improved process for preparing morphinane analogues of formula 1 wherein the substituents R, R, R, R, R, Rand Y have the meanings as defined in the specifications.

Process for the preparation of morphinane analogues

The present invention relates to an improved process for preparing morphinane analogues of formula (1) 

Stable polymorphic forms III, IV and substantially amorphous form of an anticonvulsant, tiagabine hydrochloride.

Stable polymorphic forms of an anticonvulsant

The present invention provides a process for decreasing the content of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran, a compound of formula 1, wherein X is halogen,by converting to a compound of formula 3,comprising subjecting [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran present as impurity in crude 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile to hydrogenolysis.

Process for hydrogenolysis of [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran acetamido-3-substituted-3-cephem-4-carboxylic acid

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Baroda, India

Srinivasu Kilaru