Oregon Regional Primate Research Center

Srinivasan Vijayaraghavan

Srinivasa R Nagalla

Eliot R Spindel

Anthony Archibong

Kang Li

A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.

Method of controlling fertilization using bombesin or its agonist

A pure DNA encoding a peptide which is capable of promoting acrosome reaction and the encoded peptide. Also disclosed are a vector and a cell containing such a DNA, a pharmaceutical composition which includes such a peptide, a method of promoting fertilization using such a peptide, and a method of preparing such a peptide by recombinant technology.

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Beaverton, OR, United States of America

Srinivasan Vijayaraghavan