Advanced Cardiovascular Systems, Inc.

Abbott Cardiovascular Systems, Inc.

Honeywell International Inc.

Becton Dickinson and Company Limited

Srinivasan Sridharan

Syed F A Hossainy

David C Gale

Bin Huang

Murthy V Simhambhatla

Charles David Claude

Eugene T Michal

Paul M Consigny

Evgenia Mandrusov

Jessica G Chiu

Nianjiong Joan Bei

Gregory Waimong Chan

Hongzhi Bai

Mark J Bly

Ni Ding

Florian Ludwig

Bjorn G Svensson

Carol Lee

Syed Faiyez Ahmed Hossainy

Syed F Hossainy

William Earl Webler, Jr

Arkady Kokish

Florencia Lim

Santosh V Prabhu

Benjamyn Serna

James K Hong

Mina W Chow

Klaus Kleine

Douglas H Gesswein

Gordon S Stewart

Ashok A Shah

Robert C Esselstein

Stephen G Schaible

Chi Le Long

Fernando Gonzalez

Syed Faiyaz Ahmed Hossainy

Jeong Soo Lee

Timothy A Limon

Anthony J Abbate

Gabriel Asongwe

Thomas Ray Hatten

Yan Shen

Rahul Bhagat

Tom Hatten

Edwin Wang

John Armstrong Young

Thomas Yiu-Tai Tam

James M Jacobs

K T Venkateswara Rao

Timothy Owens

Timoteo J Tomas

Delma M Blankenship

Nadine Ding

Nestor Rodriguez San Juan

Kt Venkateswara Rao

Donald James Arthur

Florian Niklas Ludwig

Syed FA Hossainy

Joe Callol

Methods are disclosed for controlling the morphology and the release-rate of active agent from coating layers for medical devices comprising a polymer matrix and one or more active agents. The methods comprise fixing the morphology or phase distribution of the active agent prior to removing solvent from the coating composition. The coating layers can be used for controlled the delivery of an active agent or a combination of active agents.

Coating layers for medical devices and method of making the same

Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

Infusion treatment agents, catheters, filter devices, and occlusion devices, and use thereof

Methods of forming coating layers for medical devices utilizing flash vaporization

Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include but are not limited to pro-fibroblastic and angiogenic agents.

Methods and compositions to treat myocardial conditions

Methods, devices, kits and compositions to treat a myocardial infarction. In one embodiment, the method includes the prevention of remodeling of the infarct zone of the ventricle. In other embodiments, the method includes the introduction of structurally reinforcing agents. In other embodiments, agents are introduced into a ventricle to increase compliance of the ventricle. In an alternative embodiment, the prevention of remodeling includes the prevention of thinning of the ventricular infarct zone. In another embodiment, the prevention of remodeling and thinning of the infarct zone involves the cross-linking of collagen and prevention of collagen slipping. In other embodiments, the structurally reinforcing agent may be accompanied by other therapeutic agents. These agents may include, but are not, limited to pro-fibroblastic and angiogenic agents.

A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.

Apparatus for selectively coating a medical article

A delivery catheter that includes a flexible shaft having a proximal end and a distal end, the distal end having an outer diameter less than about 13 mm; a delivery lumen having a proximal end and a distal end, the delivery lumen within the flexible shaft, the delivery lumen having at least an outlet port or at least one side hole at the distal end of the delivery lumen, the delivery lumen having a cross-sectional area at least about 5 mm; a pressure monitoring lumen having a proximal end and a distal end, the pressure monitoring lumen within the flexible shaft; a pressure port adjacent to and connected to the distal end of the pressure monitoring lumen; a balloon inflation lumen having a proximal end and a distal end, the balloon inflation lumen within the flexible shaft; a soft tip at the distal end of the flexible shaft; a balloon at the distal end of the flexible shaft, the balloon connected to the distal end of the balloon inflation lumen, the balloon includes at least one of the following materials, polyether block amide resin, polyetheramide, polyurethane, silicone, natural latex, or synthetic latex; wherein the balloon is adapted to inflate to a diameter range of about 4 to about 15 mm.

Retrograde pressure regulated infusion

A hybrid stent is formed which exhibits both high flexibility and high radial strength. The expandable hybrid stent for implantation in a body lumen, such as a coronary artery, consists of radially expandable cylindrical rings generally aligned on a common longitudinal axis and interconnected by one or more links. In one embodiment, a dip-coated covered stent is formed by encapsulating cylindrical rings within a polymer material. In other embodiments, at least some of the rings and links are formed of a polymer material which provides longitudinal and flexural flexibility to the stent. These polymer rings and links are alternated with metallic rings and links in various configurations to attain sufficient column strength along with the requisite flexibility in holding open the target site within the body lumen. Alternatively, a laminated, linkless hybrid stent is formed by encapsulating cylindrical rings within a polymer tube.

Hybrid intravascular stent

Methods of coating a stent subsequent to mounting or crimping of the stent on a balloon of a catheter assembly are disclosed. One method includes forming a sacrificial layer on a balloon of a catheter assembly; followed by mounting a stent on the balloon, the stent including struts separated by gaps; followed by forming a stent coating on the stent; and followed by removal of the sacrificial layer. Another method includes mounting a stent on a balloon, the stent including struts separated by gaps; followed by forming a sacrificial layer on the balloon in the areas of the gaps between struts of the stent; followed by forming a coating on the stent; and followed by removing the sacrificial layer, wherein the coating remains on an outer surface of the stent.

Methods for manufacturing a coated stent-balloon assembly

Masking apparatus and methods of masking a medical article, such as stent, for selective application of a coating composition on the article are disclosed.

Apparatus and method for selectively coating a medical article

Growing community of inventors

Morgan Hill, CA, United States of America

Srinivasan Sridharan