Vijayasri Organics Limited

Srinivasa Sastry Rani

Sairam Pothukuchi

Venkateswara Rao Tadanki

Mallikarjuna Rao Gutti

Chiranjeevi Cheekati

Trimurthulu Singavarapu

Jagapathi Raju Srivatsavayi

Mallikarjuna Rao Chikka

Venkat Reddy Thimmaipally

A process for preparation of 4-fluoro-&#x3b1;-[2-methyl-1-oxopropyl]-&#x3b3;-oxo-N-&#x3b2;-diphenylbenzene butane amide also known as a diketone intermediate of atorvastatin, completely devoid of impurities 3,4-difluoro-&#x3b1;-[2-methyl-1-oxopropyl]-&#x3b3;-oxo-n-&#x3b2;-diphenylbenzene butane amide; methyl, 2{-2[-(4-fluorophenyl)-2-oxo-1-phenylethyl)]}-4-methyl-3-oxo pentanoate; 1,4-bis(4-fluorophenyl)-2,3-diphenylbutane-1,4-dione, 1-(4-fluorophenyl)-2-phenyl ethanone; 1-(4-fluorophenyl)-2-phenyl ethanone and containing about 0.05% or less of 2-methyl-1-oxopropyl]-&#x3b3;-oxo-N-&#x3b2;-diphenylbenzene butane amide. In that process the said diketone intermediate of formula 1 is obtained by maintaining temperature &#x2212;25&#xb0; C. to 50&#xb0; C. during Friedel-Crafts acylation, in situ halogenation of formula II in presence of a solvent and nucleophilic substitution from a compound of formula III with formula IV in presence of a base.

Process for preparation of 4-fluoro-&#x3b1;-[2methyl-l-oxopropyl]-&#x3b3;-oxo&#x2014;N&#x2014;&#x3b2;-diphenylbenzene butane amide

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Hyderabad Telangana, India

Srinivasa Sastry Rani