Orion Corporation

Asana Biosciences, LLC

Dr. Reddy's Research Foundation

Dr. Reddy's Laboratories, Incorporated

Aurigene Discovery Technologies Limited

Endo Pharmaceuticals Inc.

Um Pharmauji Sdn. Bhd.

Srinivas Nanduri

Roger Astbury Smith

Sriram K Rajagopal

Subramanya Hosahalli

Mallesham Bejugam

Scott Kevin Thompson

Ranjan Chakrabarti

Gerd Wohlfahrt

Sunil Kumar Panigrahi

Venkateswarlu Akella

Subhendu Mukherjee

Srinivasan Rajagopalan

Tero Linnanen

Ravi Kotrabasaiah Ujjinamatada

Sairam Pothukuchi

Natarajan Mahalingam

Sunilkumar Bhadramma Kochunarayana Pillai

Aranapakam Mudumbai Venkatesan

Venkateshwar Rao Gummadi

Subramanya Hoshalli

Girish Aggunda Renukappa

A compound of formula (I), wherein R, R, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (1) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

Protein kinase inhibitors

A compound of formula (I), wherein R, R, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

The present application relates to novel 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives of formula (I), as protein kinase inhibitors.  The invention particularly relates to compounds of formula (I), preparation of compounds and pharmaceutical compositions thereof. The invention further relates to pharmaceutically acceptable salts and compositions comprising the said novel 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives and their use in the treatment of various disorders.

3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors

The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts, prodrugs, and solvates thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

Substituted amino-pyrimidine derivatives

The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.

Substituted quinazoline and pyrido-pyrimidine derivatives

The present invention relates to novel anticancer agents, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The present invention more particularly relates to novel derivatives of andrographolide, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, and their pharmaceutically acceptable solvates. The novel derivatives of andrographolide have the general formula (I).

Compounds having anticancer activity : process for their preparation and pharmaceutical compositions containing them

Anticancer compounds: process for their preparation and pharmaceutical compositions containing them

Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them

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Hyderabad Telangana, India

Srinivas Nanduri