Pfizer Corporation

Srinivas Kodali

Mark Edward Ruppen

Avvari Krishna Prasad

Philip R Dormitzer

Ye Che

Ping Cai

Xin Xu

Xiayang Qiu

Kena Anne Swanson

Lorna Del Pilar Nunez

Kristin Rachael Tompkins

Luke David Handke

KariAnn Sweeney Efferen

Xi Song

Alexey Vyacheslavovich Gribenko

Robert G K Donald

Annaliesa Sybil Anderson

Justin Keith Moran

Jianxin Gu

Jin-Hwan Kim

Jason Arnold Lotvin

Wei Chen

Nishith Merchant

Ling Chu

Suddham Singh

Rosalind Pan

Laurent Oliver Chorro

Scott Ellis Lomberk

Karen Kiyoko Takane

Evguenii Vinogradov

Philip Ralph Dormitzer

The present disclosure relates to RSV F protein mutants, nucleic acids or vectors encoding a RSV F protein mutant, compositions comprising a RSV F protein mutant or nucleic acid, and uses of the RSV F protein mutants, nucleic acids or vectors, and compositions.

RSV F protein mutants

In one aspect, the invention relates to an immunogenic composition comprising modified O-polysaccharide molecules derived fromlipopolysaccharides and conjugates thereof. Multivalent vaccines may be prepared by combining two or more monovalent immunogenic compositions for differentserotypes. In one embodiment, the modified O-polysaccharide molecules are produced by a recombinant bacterium that includes a wzz gene.

compositions and methods thereof

The invention relates to novel saccharides and uses thereof. In one aspect, the invention relates to a saccharide having a legionaminic acid moiety, a N-acetylgalactosamine moiety, a galactose moiety, and a glucose moiety. In another aspect, the invention relates to a saccharide having an altruronic acid moiety, a fucose moiety, and a glucose moiety. In yet another aspect, the invention relates to a saccharide having a repeating unit of a glycerol phosphate moiety and a glucose moiety, wherein the saccharide is from. In a further aspect, the invention relates to a saccharide having a repeating unit of -6-&#x3b2;-D-Fruf-2, wherein Fru is a fructose moiety, wherein the saccharide is from. In another aspect, the invention relates to an isolated antibody or fragment thereof that specifically binds to a saccharide described herein and uses thereof.

Saccharides and uses thereof

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Hillsborough, NJ, United States of America

Srinivas Kodali