Board of Trustees of the University of Arkansas

Srinivas Jayanthi

Suresh Kumar Thallapuranam

David S McNabb

Ralph L Henry

Kartik Balachandran

Alicia Brown

Jacqueline Morris

Kyle Quinn

Jingyi Chen

Shilpi Agarwal

Bhanu Prasanth Koppolu

Rebecca Kerr

Bhanuprasanth Koppolu

David A Zaharoff

Isabelle Niyonshuti

Ngoc Lam

Olivia Kolenc

Jake Jones

Tengjiao Wang

Ravi Kumar Gundampati

Sean C Smith

Engineered FGF1 and FGF2 polypeptides, polynucleotides encoding these polypeptides and DNA constructs, vectors and compositions including these engineered polypeptides are provided herein. The engineered FGF1 and FGF2 polypeptides are more stable than their wild-type counterparts and may be more effective at treating a variety of conditions that FGF1 and FGF2 are useful for treating such as wound healing.

Engineered FGF1 and FGF2 compositions and methods of use thereof

The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.

Engineered FGF compositions and methods of use thereof

In one aspect, affinity tags for recombinant protein purification are described herein which, in some embodiments, can mitigate or overcome disadvantages of prior affinity tag systems. In some embodiments, for example, affinity tags described herein permit efficient elution of desired recombinant proteins with simplified solution systems, such as alkali metal salt solutions. An affinity tag described herein comprises an amino acid sequence including a repeating amino acid unit of BXXXBXX, wherein B is an amino acid selected from the group consisting of histidine, lysine and arginine and X is an amino acid selected from the group consisting of amino acids other than histidine, lysine and arginine.

Heparin affinity tag and application thereof

Heparin affinity tag and applications thereof

Growing community of inventors

Fayetteville, AR, United States of America

Srinivas Jayanthi