Council of Scientific and Industrial Research

Srihari Pabbaraja

Ajay Kumar Singh

Subhash Ghosh

Prathama Satyendra Mainkar

Srivari Chandrasekhar

Chada Raji Reddy

Mahajan Bhushan

Taufiqueahmed Mujawar

Vinay Kumar Sthalam

Avula Shiva Krishna

Gangarajula Sudhakar

Kumaraguru Thenkrishnan

Rajesh Nasam

Goverdhan Mehta

Ramesh Samineni

Shweta Singh

The present invention relates to carbazoles of general formula (I), and process for the preparation thereof: wherein 'R' is H, C1-C6 alkyl, benzyl, or allyl; Ris H, C1-C6 alkyl, cyclopropyl, phenyl, aryl, heteroaryl, or NO; Ris H, C1-C6 alkyl, cyclopropyl, phenyl aryl, heteroaryl, 4-methoxy phenyl, 4-ethyl phenyl, 2-methyl phenyl, or 2-Fluoro phenyl; Ris H, benzoyl, —COEt, —CHO, Br, or —OMe; Ris OH, OMOM, OMe, CN, or OTf; Ris H, or O-alkyl; and R-Ris —CHNCH2CH2-. This invention also relates to the process for the preparation of carbazomycin A of Formula (1), calothrixin B of Formula (2) and staurosporinone of Formula (3) involving carbazoles of general formula (I) as an intermediate.

Indole-ynone mediated benzoannulation process for the preparation of carbazoles, carbazomycin A, calothrixin B and staurosporinone

The present invention relates to an enzymatic process for preparation of optically pure enantiomers of homopropargylic alcohol compounds of formula I, which are useful intermediates for the synthesis of Halichondrin B and analogs. wherein, P is H or an alcohol protecting group, n is an integer ranging from 0-12.

Chemo-enzymatic process for the preparation of homopropargylic alcohol

The present invention relates to preparation of pyrazoles. This invention further relates to a continuous flow micro-total process system for preparation of celecoxib, a COX-2 selective non-steroidal anti-inflammatory drug, and analogs thereof.

Continuous flow micro-total process system for preparation of celecoxib and analogs thereof

The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C&#x2014;C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.

Micro-electrolysis reactor for ultra fast, oxidant free, C&#x2014;C coupling reaction and synthesis of daclatasvir analogs thereof

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Telangana, India

Srihari Pabbaraja