Albert Einstein College of Medicine

The University of North Carolina at Chapel Hill

Drexel University

North Carolina Central University

Palacky University Olomouc

Sridhar Mani

Hao Li

Libusha Kelly

Subhajit Mukherjee

Sandhya Kortagere

Bhaskar C Das

Matthew Robert Redinbo

Felix Kopp

Li-An Yeh

John Scott

Alfred L Williams

Bret David Wallace

Kimberly Terry Lane

Chamini Karunaratne

Zdenek Dvorak

Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis of conditions such as intestinal inflammation.

Microbial hyperswarmers and uses thereof

Small molecule agonists of the pregnane X receptor (PXR), compositions and methods are disclosed for treating or preventing gut barrier dysfunction, an illness associated with gut barrier dysfunction, toxic or inflammatory injury to intestines, or leaky intestinal (gut) syndrome in a subject.

PXR agonists and uses thereof for gut barrier dysfunction treatment and prevention

Methods are disclosed for treating and preventing gut barrier dysfunction or an illness associated with gut barrier dysfunction in a subject comprising administering to the subject bacterium that produce an indole or an indole metabolite and for identifying compounds and bacteria for use in treatment and prevention of gut barrier dysfunction or an illness associated with gut barrier dysfunction.

Gut barrier dysfunction treatment and prevention

Bacterial hyperswarmers are disclosed for treatment, prevention and diagnosis conditions such as intestinal inflammation.

The application discloses ketoconazole derivatives that are antagonists of the human pregnane X receptor (PXR), methods of preparing the derivatives, uses of the derivatives with drug therapy, and methods of inhibiting tumor cell proliferation and multidrug resistance using inhibitors of PXR.

Ketoconazole-derivative antagonist of human pregnane X receptor and uses thereof

Compounds, compositions and methods are provided that comprise selective &#x3b2;-glucuronidase inhibitors for both aerobic and anaerobic bacteria, especially enteric bacteria normally associated with the gastrointestinal tract. The compounds, compositions and methods can be for inhibiting bacterial &#x3b2;-glucuronidases and for improving efficacy of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds by attenuating the side effects caused by reactivation by bacterial &#x3b2;-glucuronidases of glucuronidated metabolites of camptothecin-derived antineoplastic agents or glucuronidase-substrate agents or compounds.

Selective beta-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents

Growing community of inventors

Riverdale, NY, United States of America

Sridhar Mani