Lung Biotechnology Pbc

Mannkind Corporation

United Therapeutics Corporation

Sri Harsha Tummala

Hitesh Batra

Raju A Penmasta

Sudersan M Tuladhar

David A Walsh

Liang Guo

Patrick Poisson

Elizabeth Ann Harris

Provided are novel treprostinil based compounds, methods of treatment using the same, and their methods of making.

Prodrugs of treprostinil

Prodrugs of treprosiinil

The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.

Methods for producing Beraprost and its derivatives

The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.

Methods for producing beraprost and its derivatives

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Owings Mills, MD, United States of America

Sri Harsha Tummala