Northeastern University

Spiro Pavlopoulos

Michael Sotirios Malamas

Alexandros Makriyannis

Michael McCormack

Nikolai M Zvonok

Kyle M Whitten

Kumara Vadivel Subramanian

Jay Matthew West

A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA).

N-acylethanolamine hydrolyzing acid amidase (NAAA) inhibitors and their use thereof

A compound is represented as Formula I, a tautomer thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. Compounds of Formula I are inhibitors of N-acylethanolamine hydrolyzing acid amidase (NAAA). The present technology is directed to compounds, compositions, and methods to inhibit N-acylethanolamine hydrolyzing acid amidase and to treat N-acylethanolamine hydrolyzing acid amidase mediated conditions in a subject. 

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Spiro Pavlopoulos