Lupin, Inc.

Spinvin Venugopal

Rajender Kumar Kamboj

Kamlesh Jyotindra Padiya

Kumar Ram Naik

Bhavani Shankar Rajesh

Shaji George Kochumalayil

Prabakaran Kamalakannan

Sachin Subhash Ingawale

Rajendra Ganpati Powar

A process for manufacturing substituted chroman compounds in an economically scalable manner, without the use of pyrophoric reagents. Also disclosed herein are chroman compound synthesis routes that do not include column chromatography purification steps. The disclosure also relates to the intermediates used in the synthesis. In particular, the disclosure relates to the synthesis of the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts thereof.

Process for preparing chroman compounds

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Kochi, India

Spinvin Venugopal