Mannkind Corporation

Becton Dickinson and Company Limited

Spencer P Kinsey

Benoit Adamo

Chad C Smutney

John M Polidoro

Carl R Sahi

Vincent J Sullivan

Kenneth G Powell

Dennis Overfield

Matthew S Ferriter

Brendan F Laurenzi

Ge Jiang

Ed Browka

Melody Kuroda

John J Pocreva, Iii

Jeff Moss

Jim Fentress

Described herein are an interactive apparatus and methods for sensing and measuring real-time characteristic patterns of a subject's use of a dry powder inhalation system. The inhaler device can be used in a wireless communication mode to communicate with a display to assess the subject's usage of the inhalation system concurrently as the inhalation is performed and thus the subject's inhalation can be evaluated as well as the performance of the inhalation system. The system can also detect the identity of the medicament, its dosage, lot, expiration, etc. and the characteristics profile of a dry powder formulation emitted from the inhalation system in use.

Apparatus, system and method for detecting and monitoring inhalations

An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.

Apparatus and method for simulating inhalation efforts

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Sandy Hook, CT, United States of America

Spencer P Kinsey