Rutgers, the State University of New Jersey

University of Kentucky Research Foundation

St. Jude Children's Research Hospital

Mmv Medicines for Malaria Venture

Integurx Therapeutics, LLC

Spencer Knapp

Agis F Kydonieus

Philip D Stein

David M Floyd

Jared T Hammill

Rodney Kiplin Guy

Fangyi Zhu

David Floyd

Wendyam Armand Guiguemde

Robert D Barrows

Steve Castro

R Kiplin Guy

Christopher Davis

Philip Stein

Disclosed are methods of treating malaria with tetrahydrobenzonaphtyridine carboxanilide (TBN) derivatives and related pyrrolinones and hydrolysis products thereof. These compounds are active againststrains that are resistant to multiple drugs currently on the market. The present invention further relates to novel compounds and pharmaceutical compositions comprising such compounds.

Compositions and methods for treating malaria

The present disclosure is directed to abuse-resistant transdermal delivery compositions comprising opioid agonists.

Abuse deterrent opioid agonist transdermal compositions and methods for their use

In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl -1,2,3,4-tetrahydroisoquinoline-4-carboxamides; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating and/or preventing malaria. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Substituted 2-alkyl-1-OXO-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoquinoline-4-carboxamides for antimalarial therapies

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Skillman, NJ, United States of America

Spencer Knapp