Exxonmobil Research and Engineering Company

Sanofi

Synthetic Genomics, Inc.

Sapphire Energy, Inc.

Exxonmobile Research and Engineering Company

Soyan Leung Lieberman

Eric R Moellering

Jane C Schneider

Robert Christopher Brown

Bo Liu

John Verruto

Leah Soriaga

Craig A Behnke

Paul R August

Gena Roy

Erik Holtzapple

Shuiqin Wu

Jay McCarren

Shaun Bailey

Ariel S Schwartz

Jonathan E Meuser

Joseph C Weissman

Sridaran Natesan

Amanda Skaggs

Jamie Bacher

David Molina

Daniel Yee

Anna E Romano

Waan Jeng Huang

John H Verruto

Robert D Nielsen

Roger C Prince

Robert C Brown

Jay Mccarren

Amanda Edwards

Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutants have a locked in high light-acclimated phenotype, in which many of the photosynthetic parameters characteristic of high light acclimated wild type cells are found in the LIHLA mutants when acclimated to low light, such as reduced chlorophyll, reduced NPQ, higher qP, higher E, higher Pper unit chlorophyll with little to no reduction in Pper cell, and higher rates of electron transport through photosystem II over a wide range of light intensities. Provided herein are constructs for attenuating or disrupting genes are provided for generating mutants having the LIHLA phenotype. Also provided are methods of culturing LIHLA mutants for the production of biomass or other products.

Algal mutants having a locked-in high light acclimated phenotype

The present invention provides diacylglycerol acyltransferase (DGAT) genes, including genes encoding localization peptides. The present invention also provides recombinant cells, such as algae, transformed with DGAT genes and methods of using such recombinant cells to produce triglyceride.

DGAT genes and methods of use for triglyceride production in recombinant microorganisms

Provided herein are novel ACCases and nucleotides encoding the same, that when introduced into a cell or organism results in an increase and/or accumulation of fatty acids, glycerol lipids, and/or oils in the cell or organism, and/or a change in the types of fatty acids, glycerol lipids, and/or oils that are normally present in the cell or organism. Also provided herein are organisms transformed with the novel ACCases.

Acetyl CoA carboxylases

The present invention provides novel promoter and terminator sequences for use in gene expression in eukaryotic cells, such as algal cells. The invention further provides expression cassettes comprising a promoter, as described herein, operably linked to a gene. The invention further provides expression vectors and host eukaryotic cells, such as algal cells, for expressing a protein encoded by the gene; and methods for stably transforming eukaryotic algae such aswith transgenes.

Tetraselmis promoters and terminators for use in eukaryotic cells

The present invention relates to a composition which is useful in the treatment of a tumor, a method for making such a composition, and a method for using such a composition. The invention relates also to a method for assaying for inhibitors of the activity of Core 1 protein and/or other proteins of the respiratory complex III of mitochondria.

Composition and method for treatment of tumors

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Solana Beach, CA, United States of America

Soyan Leung Lieberman