American Cyanamid Company

Sow-Mei L Chen

Charles V Grudzinskas

Middleton B Floyd, Jr

Martin J Weiss

Allan Wissner

This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.

15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners

This disclosure describes novel 15-deoxy-16-hydroxy-16- substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion, and particularly, alkyl esters, such as the methyl ester, of such acids.

15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic

15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners

Vinylstannyl derivatives and the processes for their conversion to vinyliodides, vinylbromides and vinyllithium reagents. The vinylstannyl, vinyliodides, vinylbromide derivatives and vinyllithiums are useful as intermediates for the preparation of prostaglandin analogs.

Vinylstannyl derivatives

This disclosure describes certain 6,9.alpha.-epoxy prostacyclines and their intermediates. These compounds are useful as bronchodilators and inflammatory mediator release inhibitors.

16-Hydroxy-5-iodo-prostacyclin analogs of the 1 series

This disclosure describes certain 6,9.alpha.-epoxy prostacyclines and their intermediates. These compounds are useful as bronchodilators.

Prostacyclin analogs of the 1 series and related analogs

The invention described herein relates to novel 15-deoxy-16-hydroxy-16-ethynyl or 16-(1-propynyl) prostaglandins of E, F, D and A series having on the terminal methylene carbon of the alpha chain a substituent selected from the group consisting of: ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and C.sub.1 -C.sub.6 alkyl; R.sub.15 is selected from the group consisting of C.sub.1 -C.sub.4 alkyl, di-C.sub.1 -C.sub.4 -alkylamino, phenyl and phenyl substituted with one or more substituents selected from the group consisting of C.sub.1 -C.sub.4 alkyl, OR, SR, F or Cl, wherein R is an alkyl group.

Novel 15-deoxy-16-ethynyl and -16-(1-propynyl)-1-carboxy and 1-carbinol

15-Deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostanoic acids and congeners thereof, useful as bronchodilators, hypotensive agents, and as agents for the control of excessive gastric secretion.

Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted

Prostacyclin analogs of the 1 series and related analogs wherein the

Novel vinyl-stannyl derivatives

The invention disclosed herein relates to pharmacologically active prostaglandins of the E and F series in which C-16 is substituted with hydroxyl and fluoromethyl, difluoromethyl or trifluoromethyl as well as the pharmacologically acceptable, non-toxic lower alkyl esters and salts thereof, and to the intermediates and processes for producing such compounds.

Growing community of inventors

Park Ridge, NJ, United States of America

Sow-Mei L Chen