Vtv Therapeutics LLC

High Point Pharmaceuticals, LLC

Soumya P Sahoo

Dharma Rao Polisetti

Adnan M M Mjalli

Robert Carl Andrews

Bapu Reddy Gaddam

Mohan Rao

Rongyuan Xie

Anitha Hari

Devi Reddy Gohimukkula

Eric Joel Benjamin

Raju Bore Gowda

William Kenneth Banner

Tan Ren

Hassan El Abdellaoui

Danilo Almariego

The invention provides tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides solid compositions comprising tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist. The invention further provides uses of tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist, e.g., for treating type 1 diabetes, type 2 diabetes, or obesity.

Tris(hydroxymethyl)aminomethane salts of a small-molecule GLP1R agonist and pharmaceutical compositions and uses thereof

The present invention provides substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutically acceptable salts thereof, and tautomers of any of the foregoing, where such compounds inhibit &#x3b2;-site amyloid precursor protein-cleaving enzyme (BACE), which may be useful in the treatment of diseases in which BACE is involved, such as Alzheimer's disease. The invention also provides pharmaceutical compositions comprising any of these compounds and the use of any of these compounds and compositions in the treatment of diseases, disorders, or conditions in which BACE is involved.

Substituted imidazo[1,2-b]pyridazine derivatives, pharmaceutical compositions, and methods of use as &#x3b2;-secretase inhibitors

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Portland, ME, United States of America

Soumya P Sahoo